TY - JOUR
T1 - OnabotulinumtoxinA improves tactile and mechanical pain perception in painful diabetic polyneuropathy
AU - Chen, Wei Ta
AU - Yuan, Rey-Yue
AU - Chiang, Shu Chiung
AU - Sheu, Jau-Jiuan
AU - Yu, Jia Ming
AU - Tseng, Ing Jy
AU - Yang, Szu Kuan
AU - Chang, Hsiu Hui
AU - Hu, Chaur-Jong
PY - 2013/4
Y1 - 2013/4
N2 - OBJECTIVES:: Diabetic neuropathic pain may be relieved by onabotulinumtoxinA (BoNT/A). However, whether BoNT/A changes sensory perception in neuropathic patients remains unknown. This study used a double-blind crossover design to explore the possible effect of BoNT/A on sensory perception. METHODS:: Eighteen patients with painful diabetic polyneuropathy underwent 2 consecutive 12-week periods of treatment either in the sequence of saline (control) and then BoNT/A (SB cohort, n=9) or BoNT/A followed by saline (BS cohort, n=9). Sensory perception was assessed according to the tactile threshold [TT, logarithmized force (g) of von Frey filaments] and mechanical pain threshold [PT, logarithmized weight (g) of weighted syringes], both being averages from 4 individual measurements of bilateral medial and lateral feet obtained at baseline (before injections) and at weeks 1, 4, 8, and 12 after treatment. RESULTS:: In either the SB or the BS cohort, there was a decrease in the TT and the PT after treatment with BoNT/A but not with saline. In the analysis merging both cohorts (n=18), BoNT/A resulted in a significant decrease in TT and PT at weeks 1, 4, 8, and 12 (all Ps
AB - OBJECTIVES:: Diabetic neuropathic pain may be relieved by onabotulinumtoxinA (BoNT/A). However, whether BoNT/A changes sensory perception in neuropathic patients remains unknown. This study used a double-blind crossover design to explore the possible effect of BoNT/A on sensory perception. METHODS:: Eighteen patients with painful diabetic polyneuropathy underwent 2 consecutive 12-week periods of treatment either in the sequence of saline (control) and then BoNT/A (SB cohort, n=9) or BoNT/A followed by saline (BS cohort, n=9). Sensory perception was assessed according to the tactile threshold [TT, logarithmized force (g) of von Frey filaments] and mechanical pain threshold [PT, logarithmized weight (g) of weighted syringes], both being averages from 4 individual measurements of bilateral medial and lateral feet obtained at baseline (before injections) and at weeks 1, 4, 8, and 12 after treatment. RESULTS:: In either the SB or the BS cohort, there was a decrease in the TT and the PT after treatment with BoNT/A but not with saline. In the analysis merging both cohorts (n=18), BoNT/A resulted in a significant decrease in TT and PT at weeks 1, 4, 8, and 12 (all Ps
KW - Diabetes mellitus
KW - Neuropathic pain
KW - OnabotulinumtoxinA (BoNT/A)
KW - Pain threshold
KW - Quantitative sensory testing (QST)
KW - Tactile threshold
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U2 - 10.1097/AJP.0b013e318255c132
DO - 10.1097/AJP.0b013e318255c132
M3 - Article
C2 - 23462284
AN - SCOPUS:84874856827
SN - 0749-8047
VL - 29
SP - 305
EP - 310
JO - Clinical Journal of Pain
JF - Clinical Journal of Pain
IS - 4
ER -