Abstract
Adiponectin is regarded as a possible link between adiposity and insulin resistance. The aim of the study was to determine adipose levels of mRNA for adiponectin and adiponectin receptors (AdipoR) in non-obese women with polycystic ovary syndrome (PCOS), and to assess whether the cytokine and receptors are related to insulin resistance in PCOS. Adipose tissue obtained from eight non-obese women with PCOS [body mass index (BMI) 2 as cut-off point] was analysed. Levels of mRNA for adiponectin, AdipoR1 and 2 were quantified using the semi-quantitative reverse transcriptase-polymerase chain reaction. Eight non-obese, age-and BMI-matched healthy women served as controls. The level of adiponectin mRNA in non-obese women with PCOS were lower than in controls, but the difference was not statistically significant. However, AdipoR1 and 2 mRNA levels in non-obese women with PCOS were significantly lower than in controls. There was a significant negative correlation between 2 h insulin levels and AdipoR1 or AdipoR2 mRNA levels in non-obese women with PCOS (r = 0.45 and 0.52 respectively, P <0.05). The present study demonstrates that adiponectin receptor expression is down-regulated by hyperinsulinaemia in non-obese women with PCOS, resulting in adiponectin resistance.
Original language | English |
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Pages (from-to) | 577-582 |
Number of pages | 6 |
Journal | Reproductive BioMedicine Online |
Volume | 19 |
Issue number | 4 |
DOIs | |
Publication status | Published - Oct 2009 |
Keywords
- Adiponectin
- Adiponectin receptor 1 and 2
- Polycystic ovary syndrome
ASJC Scopus subject areas
- Reproductive Medicine
- Developmental Biology