TY - JOUR
T1 - Omega-3 fatty acids in major depressive disorder
T2 - A preliminary double-blind, placebo-controlled trial
AU - Su, Kuan Pin
AU - Huang, Shih Yi
AU - Chiu, Chih Chiang
AU - Shen, Winston W.
N1 - Funding Information:
The work was supported by the grants of NSC 90-2314-B-109-005, NSC 90-2320-B-039-042 and NSC 91-2320-B-039-010 from the National Science Council, and China Chemical and Pharmaceutical Company, Taipei, Taiwan. The authors thank Miss Chin-Hua Liu for data collection.
PY - 2003/8
Y1 - 2003/8
N2 - Patients with depression have been extensively reported to be associated with the abnormality of omega-3 polyunsaturated fatty acids (PUFAs), including significantly low eicosapentaenoic acid and docosahexaenoic acid in cell tissue contents (red blood cell membrane, plasma, etc.) and dietary intake. However, more evidence is needed to support its relation. In this study, we conducted an 8-week, double-blind, placebo-controlled trial, comparing omega-3 PUFAs (9.6 g/day) with placebo, on the top of the usual treatment, in 28 patients with major depressive disorder. Patients in the omega-3 PUFA group had a significantly decreased score on the 21-item Hamilton Rating Scale for Depression than those in the placebo group (P
AB - Patients with depression have been extensively reported to be associated with the abnormality of omega-3 polyunsaturated fatty acids (PUFAs), including significantly low eicosapentaenoic acid and docosahexaenoic acid in cell tissue contents (red blood cell membrane, plasma, etc.) and dietary intake. However, more evidence is needed to support its relation. In this study, we conducted an 8-week, double-blind, placebo-controlled trial, comparing omega-3 PUFAs (9.6 g/day) with placebo, on the top of the usual treatment, in 28 patients with major depressive disorder. Patients in the omega-3 PUFA group had a significantly decreased score on the 21-item Hamilton Rating Scale for Depression than those in the placebo group (P
KW - Diet
KW - Fish intake
KW - Major depressive disorder
KW - Nutrition therapy
KW - Omega-3 polyunsaturated fatty acids
KW - Taiwan
UR - http://www.scopus.com/inward/record.url?scp=0042850504&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0042850504&partnerID=8YFLogxK
U2 - 10.1016/S0924-977X(03)00032-4
DO - 10.1016/S0924-977X(03)00032-4
M3 - Article
C2 - 12888186
AN - SCOPUS:0042850504
SN - 0924-977X
VL - 13
SP - 267
EP - 271
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
IS - 4
ER -
