Oleic acid-enhanced transdermal delivery pathways of fluorescent nanoparticles

Wen Lo; Ara Ghazaryan; Chien Hsin Tso; Po Sheng Hu; Wei Liang Chen; Tsung Rong Kuo; Sung Jan Lin; Shean Jen Chen; Chia Chun Chen; Chen Yuan Dong

doi:10.1063/1.3701135

Oleic acid-enhanced transdermal delivery pathways of fluorescent nanoparticles

Wen Lo, Ara Ghazaryan, Chien Hsin Tso, Po Sheng Hu, Wei Liang Chen, Tsung Rong Kuo, Sung Jan Lin, Shean Jen Chen, Chia Chun Chen, Chen Yuan Dong

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Transdermal delivery of nanocarriers provides an alternative pathway to transport therapeutic agents, alleviating pain, improving compliance of patients, and increasing overall effectiveness of delivery. In this work, enhancement of transdermal delivery of fluorescent nanoparticles and sulforhodamine B with assistance of oleic acid was visualized utilizing multiphoton microscopy (MPM) and analyzed quantitatively using multi-photon excitation-induced fluorescent signals. Results of MPM imaging and MPM intensity-based spatial depth-dependent analysis showed that oleic acid is effective in facilitating transdermal delivery of nanoparticles.

Original language	English
Article number	213701
Journal	Applied Physics Letters
Volume	100
Issue number	21
DOIs	https://doi.org/10.1063/1.3701135
Publication status	Published - May 21 2012
Externally published	Yes

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

Access to Document

10.1063/1.3701135

Cite this

@article{69abfe0923314404b5dfae1b9081d6e8,

title = "Oleic acid-enhanced transdermal delivery pathways of fluorescent nanoparticles",

abstract = "Transdermal delivery of nanocarriers provides an alternative pathway to transport therapeutic agents, alleviating pain, improving compliance of patients, and increasing overall effectiveness of delivery. In this work, enhancement of transdermal delivery of fluorescent nanoparticles and sulforhodamine B with assistance of oleic acid was visualized utilizing multiphoton microscopy (MPM) and analyzed quantitatively using multi-photon excitation-induced fluorescent signals. Results of MPM imaging and MPM intensity-based spatial depth-dependent analysis showed that oleic acid is effective in facilitating transdermal delivery of nanoparticles.",

author = "Wen Lo and Ara Ghazaryan and Tso, {Chien Hsin} and Hu, {Po Sheng} and Chen, {Wei Liang} and Kuo, {Tsung Rong} and Lin, {Sung Jan} and Chen, {Shean Jen} and Chen, {Chia Chun} and Dong, {Chen Yuan}",

year = "2012",

month = may,

day = "21",

doi = "10.1063/1.3701135",

language = "English",

volume = "100",

journal = "Applied Physics Letters",

issn = "0003-6951",

publisher = "American Institute of Physics",

number = "21",

}

TY - JOUR

T1 - Oleic acid-enhanced transdermal delivery pathways of fluorescent nanoparticles

AU - Lo, Wen

AU - Ghazaryan, Ara

AU - Tso, Chien Hsin

AU - Hu, Po Sheng

AU - Chen, Wei Liang

AU - Kuo, Tsung Rong

AU - Lin, Sung Jan

AU - Chen, Shean Jen

AU - Chen, Chia Chun

AU - Dong, Chen Yuan

PY - 2012/5/21

Y1 - 2012/5/21

N2 - Transdermal delivery of nanocarriers provides an alternative pathway to transport therapeutic agents, alleviating pain, improving compliance of patients, and increasing overall effectiveness of delivery. In this work, enhancement of transdermal delivery of fluorescent nanoparticles and sulforhodamine B with assistance of oleic acid was visualized utilizing multiphoton microscopy (MPM) and analyzed quantitatively using multi-photon excitation-induced fluorescent signals. Results of MPM imaging and MPM intensity-based spatial depth-dependent analysis showed that oleic acid is effective in facilitating transdermal delivery of nanoparticles.

AB - Transdermal delivery of nanocarriers provides an alternative pathway to transport therapeutic agents, alleviating pain, improving compliance of patients, and increasing overall effectiveness of delivery. In this work, enhancement of transdermal delivery of fluorescent nanoparticles and sulforhodamine B with assistance of oleic acid was visualized utilizing multiphoton microscopy (MPM) and analyzed quantitatively using multi-photon excitation-induced fluorescent signals. Results of MPM imaging and MPM intensity-based spatial depth-dependent analysis showed that oleic acid is effective in facilitating transdermal delivery of nanoparticles.

UR - http://www.scopus.com/inward/record.url?scp=84861831529&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84861831529&partnerID=8YFLogxK

U2 - 10.1063/1.3701135

DO - 10.1063/1.3701135

M3 - Article

AN - SCOPUS:84861831529

SN - 0003-6951

VL - 100

JO - Applied Physics Letters

JF - Applied Physics Letters

IS - 21

M1 - 213701

ER -

Oleic acid-enhanced transdermal delivery pathways of fluorescent nanoparticles

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this