TY - JOUR
T1 - Ochratoxin a-induced nephrotoxicity
T2 - Up-to-date evidence
AU - Khoi, Chong Sun
AU - Chen, Jia Huang
AU - Lin, Tzu Yu
AU - Chiang, Chih Kang
AU - Hung, Kuan Yu
N1 - Funding Information:
This study was funded by grants from the Taiwan Ministry of Science and Technology (MOST-104-2314-B-002-126-MY3, MOST-107-2314-B-002-027-MY3 and MOST-110-2314-B-002-130) and grants from the National Taiwan University Hospital (NTUH-106-S3574 and NTUH-107-S3826, NTUH.108-P02, NTUH-110-S5063), and NTUH-FEMH Joint research program (110-FTN21).
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/10/1
Y1 - 2021/10/1
N2 - Ochratoxin A (OTA) is a mycotoxin widely found in various foods and feeds that have a deleterious effect on humans and animals. It has been shown that OTA causes multiorgan toxicity, and the kidney is the main target of OTA among them. This present article aims to review recent and latest intracellular molecular interactions and signaling pathways of OTA-induced nephrotoxicity. Pyroptosis, lipotoxicity, organic anionic membrane transporter, autophagy, the ubiquitin-proteasome system, and histone acetyltransferase have been involved in the renal toxicity caused by OTA. Meanwhile, the literature reviewed the alternative or method against OTA toxicity by reducing ROS production, oxidative stress, activating the Nrf2 pathway, through using nanoparticles, a natural flavonoid, and metal supplement. The present review discloses the molecular mechanism of OTA-induced nephrotoxicity, providing opinions and strategies against OTA toxicity.
AB - Ochratoxin A (OTA) is a mycotoxin widely found in various foods and feeds that have a deleterious effect on humans and animals. It has been shown that OTA causes multiorgan toxicity, and the kidney is the main target of OTA among them. This present article aims to review recent and latest intracellular molecular interactions and signaling pathways of OTA-induced nephrotoxicity. Pyroptosis, lipotoxicity, organic anionic membrane transporter, autophagy, the ubiquitin-proteasome system, and histone acetyltransferase have been involved in the renal toxicity caused by OTA. Meanwhile, the literature reviewed the alternative or method against OTA toxicity by reducing ROS production, oxidative stress, activating the Nrf2 pathway, through using nanoparticles, a natural flavonoid, and metal supplement. The present review discloses the molecular mechanism of OTA-induced nephrotoxicity, providing opinions and strategies against OTA toxicity.
KW - Molecular interaction
KW - Nephrotoxicity
KW - Ochratoxin A
KW - Prevention
UR - https://www.scopus.com/pages/publications/85117130809
UR - https://www.scopus.com/inward/citedby.url?scp=85117130809&partnerID=8YFLogxK
U2 - 10.3390/ijms222011237
DO - 10.3390/ijms222011237
M3 - Review article
C2 - 34681895
AN - SCOPUS:85117130809
SN - 1661-6596
VL - 22
JO - International journal of molecular sciences
JF - International journal of molecular sciences
IS - 20
M1 - 11237
ER -