Ochratoxin a-induced nephrotoxicity: Up-to-date evidence

Chong Sun Khoi, Jia Huang Chen, Tzu Yu Lin, Chih Kang Chiang, Kuan Yu Hung

Research output: Contribution to journalReview articlepeer-review

35 Citations (Scopus)

Abstract

Ochratoxin A (OTA) is a mycotoxin widely found in various foods and feeds that have a deleterious effect on humans and animals. It has been shown that OTA causes multiorgan toxicity, and the kidney is the main target of OTA among them. This present article aims to review recent and latest intracellular molecular interactions and signaling pathways of OTA-induced nephrotoxicity. Pyroptosis, lipotoxicity, organic anionic membrane transporter, autophagy, the ubiquitin-proteasome system, and histone acetyltransferase have been involved in the renal toxicity caused by OTA. Meanwhile, the literature reviewed the alternative or method against OTA toxicity by reducing ROS production, oxidative stress, activating the Nrf2 pathway, through using nanoparticles, a natural flavonoid, and metal supplement. The present review discloses the molecular mechanism of OTA-induced nephrotoxicity, providing opinions and strategies against OTA toxicity.

Original languageEnglish
Article number11237
JournalInternational journal of molecular sciences
Volume22
Issue number20
DOIs
Publication statusPublished - Oct 1 2021
Externally publishedYes

Keywords

  • Molecular interaction
  • Nephrotoxicity
  • Ochratoxin A
  • Prevention

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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