Obesity and insulin resistance in women with polycystic ovary syndrome

Hsu Chun-Sen, Wu Chien-Hua, Chiu Wan-Chun, Lee Ching-Tzu, Chang Chun-Jen, Hsu Ming-I

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Objective. To evaluate the impact of obesity and various phenotypes of polycystic ovary syndrome (PCOS) on the insulin sensitivity index (ISI) and insulin resistance (IR). Methods. ISI and IR from 273 women in four phenotypes of PCOS and control groups were evaluated retrospectively. Results. The ISI and the percentage of IR were not significantly different among discrete phenotypes of PCOS groups and normal controls. Obesity (OR = 14.0, 95% CI (Confidence Interval), 7.5-26.5) results in a higher risk for developing insulin resistance than hyperandrogenemia (OR = 2.1, 1.3-3.6), oligomenorrhea (OR = 1.8, 1.0-3.3) and polycystic ovary morphology (PCOM) (OR = 1.4, 0.8-2.7). Conclusion. The ISI did not differ significantly among the various phenotypes of PCOS. In comparison with hyperandrogenemia, chronic anovulation, and PCOM, obesity was the dominant risk factor in determining insulin resistance in women with PCOS.

Original languageEnglish
Pages (from-to)300-306
Number of pages7
JournalGynecological Endocrinology
Issue number5
Publication statusPublished - May 2011


  • Polycystic ovary syndrome
  • insulin resistance
  • obesity
  • phenotypes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Obstetrics and Gynaecology


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