TY - JOUR
T1 - Obesity and inflammatory biomarkers in women with polycystic ovary syndrome
AU - Shen, Szu Hung
AU - Shen, Szu Yu
AU - Liou, Tsan Hon
AU - Hsu, Ming I.
AU - Chang, Yuan Chin Ivan
AU - Cheng, Chih Yu
AU - Hsu, Chun-Sen
AU - Tzeng, Chii Ruey
N1 - Funding Information:
This work was supported by the Taiwan National Science Council Grant NSC 102-2629-B-038-001 and Taipei Medical University – Wan Fang Hospital Grant 103-wf-eva-10 .
Publisher Copyright:
© 2015 Elsevier Ireland Ltd.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Abstract Objective To evaluate the roles of obesity and inflammatory biomarkers associated with medical complications in women with PCOS. Study design Retrospective, BMI-matched study. A total of 330 patients, including 165 women with PCOS and 165 women without PCOS, were evaluated. The insulin resistance (homeostasis model assessment insulin resistance index - HOMA) and lipid profiles were assessed. The adiponectin, leptin, ghrelin, resistin, anti-müllerian hormone (AMH), sex hormone-binding globulin (SHBG), high sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6) levels were also measured. Results Women with PCOS had significantly higher AMH, fasting insulin, total cholesterol, and low-density lipoprotein levels and lower SHBG levels compared with the controls. There was no difference in the serum obesity and inflammatory biomarkers between the PCOS cases and the controls. After adjusting for BMI and age, IL-6 was positively correlated with HOMA, and SHBG was negatively correlated with HOMA, triglyceride, and LDL. Conclusions The serum adipokines levels are not good markers for PCOS. PCOS patients were characterized by their high AMH and low SHBG levels. A low level of SHBG should play an important role in the pathogenesis of the medical complications observed in women with PCOS. Clinical trial registration number NCT01989039.
AB - Abstract Objective To evaluate the roles of obesity and inflammatory biomarkers associated with medical complications in women with PCOS. Study design Retrospective, BMI-matched study. A total of 330 patients, including 165 women with PCOS and 165 women without PCOS, were evaluated. The insulin resistance (homeostasis model assessment insulin resistance index - HOMA) and lipid profiles were assessed. The adiponectin, leptin, ghrelin, resistin, anti-müllerian hormone (AMH), sex hormone-binding globulin (SHBG), high sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6) levels were also measured. Results Women with PCOS had significantly higher AMH, fasting insulin, total cholesterol, and low-density lipoprotein levels and lower SHBG levels compared with the controls. There was no difference in the serum obesity and inflammatory biomarkers between the PCOS cases and the controls. After adjusting for BMI and age, IL-6 was positively correlated with HOMA, and SHBG was negatively correlated with HOMA, triglyceride, and LDL. Conclusions The serum adipokines levels are not good markers for PCOS. PCOS patients were characterized by their high AMH and low SHBG levels. A low level of SHBG should play an important role in the pathogenesis of the medical complications observed in women with PCOS. Clinical trial registration number NCT01989039.
KW - Adiponectin
KW - Inflammation
KW - Leptin
KW - Obesity
KW - PCOS
KW - Resistin
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U2 - 10.1016/j.ejogrb.2015.06.022
DO - 10.1016/j.ejogrb.2015.06.022
M3 - Article
C2 - 26177495
AN - SCOPUS:84938527318
SN - 0028-2243
VL - 192
SP - 66
EP - 71
JO - European Journal of Obstetrics and Gynecology and Reproductive Biology
JF - European Journal of Obstetrics and Gynecology and Reproductive Biology
M1 - 9031
ER -
