Novel terpenoids from Calocedrus macrolepis var. formosana

Chin Lin Hsieh, Mei Hwei Tseng, Ryh Nan Pan, Jang Yang Chang, Ching Chuan Kuo, Zong-Huei Li, Yueh Hsiung Kuo

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Calocetriol (1), diacetylcalocediol (2), and ferrugimenthenol (3) were isolated from the bark of Calocedrus macrolepis var. formosana. Among them, 1 and 2 are secoabietane-type diterpenoids, and 3, with a novel C 20-C 10 skeleton, is classified as a meroterpenoid. The structures of 1-3 were elucidated by spectroscopic analyses, and their biological activities were also evaluated. Compound 3 exhibited significant cytotoxic activity against human oral epidermoid carcinoma KB cells with an IC 50 value of 9.0±0.1 μM.

Original languageEnglish
Pages (from-to)1901-1907
Number of pages7
JournalChemistry and Biodiversity
Issue number10
Publication statusPublished - Oct 2011


  • Calocedrus macrolepis var. formosana
  • Calocetriol
  • Cytotoxic activity
  • Diacetylcalocetriol
  • Diterpenoids
  • Ferrugimenthenol
  • Meroterpenoids
  • Secoabietanes

ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)
  • Bioengineering
  • Molecular Biology
  • Molecular Medicine


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