Novel terpenoids from Calocedrus macrolepis var. formosana

Chin Lin Hsieh; Mei Hwei Tseng; Ryh Nan Pan; Jang Yang Chang; Ching Chuan Kuo; Zong-Huei Li; Yueh Hsiung Kuo

doi:10.1002/cbdv.201000237

Novel terpenoids from Calocedrus macrolepis var. formosana

Chin Lin Hsieh, Mei Hwei Tseng, Ryh Nan Pan, Jang Yang Chang, Ching Chuan Kuo, Zong-Huei Li, Yueh Hsiung Kuo

Graduate Institute of Pharmacognosy

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Calocetriol (1), diacetylcalocediol (2), and ferrugimenthenol (3) were isolated from the bark of Calocedrus macrolepis var. formosana. Among them, 1 and 2 are secoabietane-type diterpenoids, and 3, with a novel C ₂₀-C ₁₀ skeleton, is classified as a meroterpenoid. The structures of 1-3 were elucidated by spectroscopic analyses, and their biological activities were also evaluated. Compound 3 exhibited significant cytotoxic activity against human oral epidermoid carcinoma KB cells with an IC ₅₀ value of 9.0±0.1 μM.

Original language	English
Pages (from-to)	1901-1907
Number of pages	7
Journal	Chemistry and Biodiversity
Volume	8
Issue number	10
DOIs	https://doi.org/10.1002/cbdv.201000237
Publication status	Published - Oct 2011

Keywords

Calocedrus macrolepis var. formosana
Calocetriol
Cytotoxic activity
Diacetylcalocetriol
Diterpenoids
Ferrugimenthenol
Meroterpenoids
Secoabietanes

ASJC Scopus subject areas

Biochemistry
General Chemistry
Bioengineering
Molecular Biology
Molecular Medicine

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10.1002/cbdv.201000237

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title = "Novel terpenoids from Calocedrus macrolepis var. formosana",

abstract = "Calocetriol (1), diacetylcalocediol (2), and ferrugimenthenol (3) were isolated from the bark of Calocedrus macrolepis var. formosana. Among them, 1 and 2 are secoabietane-type diterpenoids, and 3, with a novel C 20-C 10 skeleton, is classified as a meroterpenoid. The structures of 1-3 were elucidated by spectroscopic analyses, and their biological activities were also evaluated. Compound 3 exhibited significant cytotoxic activity against human oral epidermoid carcinoma KB cells with an IC 50 value of 9.0±0.1 μM.",

keywords = "Calocedrus macrolepis var. formosana, Calocetriol, Cytotoxic activity, Diacetylcalocetriol, Diterpenoids, Ferrugimenthenol, Meroterpenoids, Secoabietanes",

author = "Hsieh, {Chin Lin} and Tseng, {Mei Hwei} and Pan, {Ryh Nan} and Chang, {Jang Yang} and Kuo, {Ching Chuan} and Zong-Huei Li and Kuo, {Yueh Hsiung}",

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AU - Hsieh, Chin Lin

AU - Tseng, Mei Hwei

AU - Pan, Ryh Nan

AU - Chang, Jang Yang

AU - Kuo, Ching Chuan

AU - Li, Zong-Huei

AU - Kuo, Yueh Hsiung

PY - 2011/10

Y1 - 2011/10

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KW - Calocedrus macrolepis var. formosana

KW - Calocetriol

KW - Cytotoxic activity

KW - Diacetylcalocetriol

KW - Diterpenoids

KW - Ferrugimenthenol

KW - Meroterpenoids

KW - Secoabietanes

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Novel terpenoids from Calocedrus macrolepis var. formosana

Abstract

Keywords

ASJC Scopus subject areas

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