Abstract
Sequencing analyses of genomic DNA samples from a Chinese population identified four single-nucleotide polymorphisms (SNPs) of the CRTH2 gene, encoding a chemoattractant receptor predominantly expressed on Th2 cells and a receptor for prostaglandin D2 (PGD2). Two coding-region SNPs with a T to G and a C to A substitutions, resulting in codon changes from Phe to Val and Pro to Thr, respectively. Two additional SNPs were discovered in the 3′ untranslated region (3′-UTR). These newly identified SNPs will be useful for further functional study of variant CRTH2 gene, and for genetic studies of asthma and other immunologic diseases.
Original language | English |
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Pages (from-to) | 114-116 |
Number of pages | 3 |
Journal | Genes and Immunity |
Volume | 3 |
Issue number | 2 |
DOIs | |
Publication status | Published - Apr 2002 |
Keywords
- Allergic diseases
- CRTH2 gene
- SNP
ASJC Scopus subject areas
- Genetics(clinical)
- Genetics
- Immunology