Novel SNPs in a candidate gene, CRTH2, for allergic diseases

S. C. Hsu, L. C. Chen, M. L. Kuo, J. Long Huang, S. K. Huang

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Sequencing analyses of genomic DNA samples from a Chinese population identified four single-nucleotide polymorphisms (SNPs) of the CRTH2 gene, encoding a chemoattractant receptor predominantly expressed on Th2 cells and a receptor for prostaglandin D2 (PGD2). Two coding-region SNPs with a T to G and a C to A substitutions, resulting in codon changes from Phe to Val and Pro to Thr, respectively. Two additional SNPs were discovered in the 3′ untranslated region (3′-UTR). These newly identified SNPs will be useful for further functional study of variant CRTH2 gene, and for genetic studies of asthma and other immunologic diseases.

Original languageEnglish
Pages (from-to)114-116
Number of pages3
JournalGenes and Immunity
Issue number2
Publication statusPublished - Apr 2002


  • Allergic diseases
  • CRTH2 gene
  • SNP

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics
  • Immunology


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