Novel injectable thermosensitive hydrogels for delivering hyaluronic acid-doxorubicin nanocomplexes to locally treat tumors

Hua Jing Jhan; Jun Jen Liu; Ying Chen Chen; Der Zen Liu; Ming Thau Sheu; Hsiu O. Ho

doi:10.2217/nnm.14.211

Novel injectable thermosensitive hydrogels for delivering hyaluronic acid-doxorubicin nanocomplexes to locally treat tumors

Hua Jing Jhan, Jun Jen Liu, Ying Chen Chen, Der Zen Liu, Ming Thau Sheu, Hsiu O. Ho

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Aim: A thermosensitive injectable hydrogel composed of nanocomplexes of doxorubicin and hyaluronic acid (HA) for the local treatment of cancer diseases was developed and characterized. Materials & methods: It was found that the addition of a divalent metal ion of Mg (MgCl₂) was required to properly form HA-doxorubicin nanocomplexes, which were mixed with Pluronic^® F127 (BASF, Germany) to form thermosensitive injectable hydrogels. Results: The DH_700KMF-15 hydrogel resulted in efficient growth inhibition of C26 colon cancer cells and it selectively targeted the lymphatic system by the specific affinity of HA to the lymphatic system in vivo. Conclusion: The optimal formulations of DH_700KMF-15 can increase the therapeutic efficacy of the local treatment of cancer with the potential for lymphotropic targeting to inhibit metastasis.

Original language	English
Pages (from-to)	1263-1274
Number of pages	12
Journal	Nanomedicine
Volume	10
Issue number	8
DOIs	https://doi.org/10.2217/nnm.14.211
Publication status	Published - Apr 1 2015

Keywords

Pluronic F127
doxorubicin
hyaluronic acid
hydrogel
intratumoral

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
General Materials Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/nnm.14.211

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title = "Novel injectable thermosensitive hydrogels for delivering hyaluronic acid-doxorubicin nanocomplexes to locally treat tumors",

abstract = "Aim: A thermosensitive injectable hydrogel composed of nanocomplexes of doxorubicin and hyaluronic acid (HA) for the local treatment of cancer diseases was developed and characterized. Materials & methods: It was found that the addition of a divalent metal ion of Mg (MgCl2) was required to properly form HA-doxorubicin nanocomplexes, which were mixed with Pluronic{\textregistered} F127 (BASF, Germany) to form thermosensitive injectable hydrogels. Results: The DH700KMF-15 hydrogel resulted in efficient growth inhibition of C26 colon cancer cells and it selectively targeted the lymphatic system by the specific affinity of HA to the lymphatic system in vivo. Conclusion: The optimal formulations of DH700KMF-15 can increase the therapeutic efficacy of the local treatment of cancer with the potential for lymphotropic targeting to inhibit metastasis.",

keywords = "Pluronic F127, doxorubicin, hyaluronic acid, hydrogel, intratumoral",

author = "Jhan, {Hua Jing} and Liu, {Jun Jen} and Chen, {Ying Chen} and Liu, {Der Zen} and Sheu, {Ming Thau} and Ho, {Hsiu O.}",

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doi = "10.2217/nnm.14.211",

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AU - Jhan, Hua Jing

AU - Liu, Jun Jen

AU - Chen, Ying Chen

AU - Liu, Der Zen

AU - Sheu, Ming Thau

AU - Ho, Hsiu O.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Aim: A thermosensitive injectable hydrogel composed of nanocomplexes of doxorubicin and hyaluronic acid (HA) for the local treatment of cancer diseases was developed and characterized. Materials & methods: It was found that the addition of a divalent metal ion of Mg (MgCl2) was required to properly form HA-doxorubicin nanocomplexes, which were mixed with Pluronic® F127 (BASF, Germany) to form thermosensitive injectable hydrogels. Results: The DH700KMF-15 hydrogel resulted in efficient growth inhibition of C26 colon cancer cells and it selectively targeted the lymphatic system by the specific affinity of HA to the lymphatic system in vivo. Conclusion: The optimal formulations of DH700KMF-15 can increase the therapeutic efficacy of the local treatment of cancer with the potential for lymphotropic targeting to inhibit metastasis.

AB - Aim: A thermosensitive injectable hydrogel composed of nanocomplexes of doxorubicin and hyaluronic acid (HA) for the local treatment of cancer diseases was developed and characterized. Materials & methods: It was found that the addition of a divalent metal ion of Mg (MgCl2) was required to properly form HA-doxorubicin nanocomplexes, which were mixed with Pluronic® F127 (BASF, Germany) to form thermosensitive injectable hydrogels. Results: The DH700KMF-15 hydrogel resulted in efficient growth inhibition of C26 colon cancer cells and it selectively targeted the lymphatic system by the specific affinity of HA to the lymphatic system in vivo. Conclusion: The optimal formulations of DH700KMF-15 can increase the therapeutic efficacy of the local treatment of cancer with the potential for lymphotropic targeting to inhibit metastasis.

KW - Pluronic F127

KW - doxorubicin

KW - hyaluronic acid

KW - hydrogel

KW - intratumoral

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Novel injectable thermosensitive hydrogels for delivering hyaluronic acid-doxorubicin nanocomplexes to locally treat tumors

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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