Novel biomarker analysis of pleural effusion enhances differentiation of tuberculous from malignant pleural effusion

Kuan Yuan Chen; Po Hao Feng; Chih Cheng Chang; Tzu Tao Chen; Hsiao Chi Chuang; Chun Nin Lee; Chien Ling Su; Lian Yu Lin; Kang Yun Lee

doi:10.2147/IJGM.S100237

Novel biomarker analysis of pleural effusion enhances differentiation of tuberculous from malignant pleural effusion

Kuan Yuan Chen, Po Hao Feng, Chih Cheng Chang, Tzu Tao Chen, Hsiao Chi Chuang, Chun Nin Lee, Chien Ling Su, Lian Yu Lin, Kang Yun Lee

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Lymphocytic pleurisy is commonly observed in tuberculosis and cancer. Noninvasive biomarkers are needed to distinguish tuberculous pleural effusion (TPE) from malignant pleural effusion (MPE) because current clinical diagnostic procedures are often invasive. We identified immune response biomarkers that can discriminate between TPE and MPE. Fourteen pleural effusion biomarkers were compared in 22 MPE patients and five TPE patients. Of the innate immunity biomarkers, the median levels of interleukin (IL)-1βand interferon-induced protein-10 (IP-10) were higher in TPE patients than in MPE patients (P

Original language	English
Pages (from-to)	183-189
Number of pages	7
Journal	International Journal of General Medicine
Volume	9
DOIs	https://doi.org/10.2147/IJGM.S100237
Publication status	Published - Jun 11 2016

Keywords

Biomarkers
Lung cancer
Malignant pleural effusion
Tuberculous pleural effusion

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2147/IJGM.S100237

Cite this

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title = "Novel biomarker analysis of pleural effusion enhances differentiation of tuberculous from malignant pleural effusion",

abstract = "Lymphocytic pleurisy is commonly observed in tuberculosis and cancer. Noninvasive biomarkers are needed to distinguish tuberculous pleural effusion (TPE) from malignant pleural effusion (MPE) because current clinical diagnostic procedures are often invasive. We identified immune response biomarkers that can discriminate between TPE and MPE. Fourteen pleural effusion biomarkers were compared in 22 MPE patients and five TPE patients. Of the innate immunity biomarkers, the median levels of interleukin (IL)-1βand interferon-induced protein-10 (IP-10) were higher in TPE patients than in MPE patients (P",

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doi = "10.2147/IJGM.S100237",

language = "English",

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T1 - Novel biomarker analysis of pleural effusion enhances differentiation of tuberculous from malignant pleural effusion

AU - Chen, Kuan Yuan

AU - Feng, Po Hao

AU - Chang, Chih Cheng

AU - Chen, Tzu Tao

AU - Chuang, Hsiao Chi

AU - Lee, Chun Nin

AU - Su, Chien Ling

AU - Lin, Lian Yu

AU - Lee, Kang Yun

PY - 2016/6/11

Y1 - 2016/6/11

N2 - Lymphocytic pleurisy is commonly observed in tuberculosis and cancer. Noninvasive biomarkers are needed to distinguish tuberculous pleural effusion (TPE) from malignant pleural effusion (MPE) because current clinical diagnostic procedures are often invasive. We identified immune response biomarkers that can discriminate between TPE and MPE. Fourteen pleural effusion biomarkers were compared in 22 MPE patients and five TPE patients. Of the innate immunity biomarkers, the median levels of interleukin (IL)-1βand interferon-induced protein-10 (IP-10) were higher in TPE patients than in MPE patients (P

AB - Lymphocytic pleurisy is commonly observed in tuberculosis and cancer. Noninvasive biomarkers are needed to distinguish tuberculous pleural effusion (TPE) from malignant pleural effusion (MPE) because current clinical diagnostic procedures are often invasive. We identified immune response biomarkers that can discriminate between TPE and MPE. Fourteen pleural effusion biomarkers were compared in 22 MPE patients and five TPE patients. Of the innate immunity biomarkers, the median levels of interleukin (IL)-1βand interferon-induced protein-10 (IP-10) were higher in TPE patients than in MPE patients (P

KW - Biomarkers

KW - Lung cancer

KW - Malignant pleural effusion

KW - Tuberculous pleural effusion

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DO - 10.2147/IJGM.S100237

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Novel biomarker analysis of pleural effusion enhances differentiation of tuberculous from malignant pleural effusion

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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