TY - JOUR
T1 - Nonmyeloablative allogeneic bone marrow transplantation for orbital granulocytic sarcoma associated with t(8;21)(q22;q22) in acute myeloid leukemia
AU - Hung, G. Y.
AU - Chiou, T. J.
AU - Hsieh, Y. L.
AU - Chen, P. M.
AU - Hwang, B.
PY - 2002
Y1 - 2002
N2 - We report a nonmyeloablative allogeneic bone marrow transplant (allo-BMT) from an HLA-matched unrelated donor in a case of acute myeloid leukemia (AML), M2 with t(8;21)(q22;q22) and the presence of orbital granulocytic sarcoma (GS), who had residual tumor after conventional chemotherapy. The course of BMT was well tolerated, with no major procedure-related toxicity. The residual orbital GS regressed completely 4 months after BMT. She is currently 19 months post BMT, disease-free. To our knowledge, this is the first reported pediatric patient with AML, GS and t(8;21)(q22;q22) who received a nonmyeloablative allo-BMT.
AB - We report a nonmyeloablative allogeneic bone marrow transplant (allo-BMT) from an HLA-matched unrelated donor in a case of acute myeloid leukemia (AML), M2 with t(8;21)(q22;q22) and the presence of orbital granulocytic sarcoma (GS), who had residual tumor after conventional chemotherapy. The course of BMT was well tolerated, with no major procedure-related toxicity. The residual orbital GS regressed completely 4 months after BMT. She is currently 19 months post BMT, disease-free. To our knowledge, this is the first reported pediatric patient with AML, GS and t(8;21)(q22;q22) who received a nonmyeloablative allo-BMT.
KW - Acute myeloid leukemia
KW - Granulocytic sarcoma
KW - Nonmyeloablative bone marrow transplantation
UR - http://www.scopus.com/inward/record.url?scp=85047700146&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85047700146&partnerID=8YFLogxK
U2 - 10.1038/sj.bmt.1703316
DO - 10.1038/sj.bmt.1703316
M3 - Article
C2 - 11840147
AN - SCOPUS:85047700146
SN - 0268-3369
VL - 29
SP - 67
EP - 70
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
IS - 1
ER -