Nonhistone proteins HMG1 and HMG2 change the DNA helical structure

Kashayar Javaherian, Leroy F. Liu, James C. Wang

Research output: Contribution to journalArticlepeer-review

204 Citations (Scopus)

Abstract

Two chromatin nonhistone proteins (from calf thymus) of the high mobility group, HMG1 and HMG2, reduce the linking number (topological winding number) of a circular DNA if the covalent closure of the DNA is carried out in their presence. This indicates that these proteins can either unwind the double helix, or induce a supercoiling of the DNA.

Original languageEnglish
Pages (from-to)1345-1346
Number of pages2
JournalScience
Volume199
Issue number4335
DOIs
Publication statusPublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • General

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