Abstract
Two chromatin nonhistone proteins (from calf thymus) of the high mobility group, HMG1 and HMG2, reduce the linking number (topological winding number) of a circular DNA if the covalent closure of the DNA is carried out in their presence. This indicates that these proteins can either unwind the double helix, or induce a supercoiling of the DNA.
Original language | English |
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Pages (from-to) | 1345-1346 |
Number of pages | 2 |
Journal | Science |
Volume | 199 |
Issue number | 4335 |
DOIs | |
Publication status | Published - 1978 |
Externally published | Yes |
ASJC Scopus subject areas
- General