TY - JOUR
T1 - Non-Watson-Crick G. C and A. T Base Pairs in a DNA-antibiotic complex
AU - Quigley, Gary J.
AU - Ughetto, Giovanni
AU - Van Der Marel, Gijs A.
AU - Van Boom, Jacques H.
AU - Wang, Andrew H.J.
AU - Rich, Alexander
PY - 1986
Y1 - 1986
N2 - The structure of a DNA octamer d(GCGTACGC) cocrystallized with the bisintercalator antibiotic triostin A has been solved. The DNA forms an unwound right-handed double helix. Four base pairs are of the Watson-Crick type while four are Hoogsteen base pairs, including two A · T and two G · C base pairs. This is the first observation in an oligonucleotide of Hoogsteen G · C base pairs where the cystosine is protonated. It is likely that these also occur in solutions of DNA complexed to this antibiotic.
AB - The structure of a DNA octamer d(GCGTACGC) cocrystallized with the bisintercalator antibiotic triostin A has been solved. The DNA forms an unwound right-handed double helix. Four base pairs are of the Watson-Crick type while four are Hoogsteen base pairs, including two A · T and two G · C base pairs. This is the first observation in an oligonucleotide of Hoogsteen G · C base pairs where the cystosine is protonated. It is likely that these also occur in solutions of DNA complexed to this antibiotic.
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U2 - 10.1126/science.3704650
DO - 10.1126/science.3704650
M3 - Article
C2 - 3704650
AN - SCOPUS:0022457809
SN - 0036-8075
VL - 232
SP - 1255
EP - 1258
JO - Science
JF - Science
IS - 4755
ER -