No association of alpha-2 macroglobulin gene five-nucleotide deletion with AD in Taiwan Chinese

C. J. Hu; S. M. Sung; H. C. Liu; K. Y. Lee; W. C. Hsu; W. K. Wong; C. C. Lee; C. H. Tsai; Jan Gowth Chang

doi:10.1212/wnl.53.3.642

No association of alpha-2 macroglobulin gene five-nucleotide deletion with AD in Taiwan Chinese

C. J. Hu
, S. M. Sung
, H. C. Liu
, K. Y. Lee
, W. C. Hsu
, W. K. Wong
, C. C. Lee
, C. H. Tsai
, Jan Gowth Chang

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

The alpha-2 macroglobulin five-nucleotide deletion (A2M-2) allele frequency was not significantly higher in the AD group than the control group (0.062 versus 0.101, p > 0.1). The odds ratio for AD in individuals with the A2M-2 allele was 0.582 (95% CI, 0.25 to 1.40). These results do not support the association between A2M-2 and AD in the Chinese population, although the allele frequency of A2M-2 is lower than that found in the Caucasian population. Therefore, A2M-2 might not be a significant risk factor of AD among Taiwan Chinese.

Original language	English
Pages (from-to)	642-643
Number of pages	2
Journal	Neurology
Volume	53
Issue number	3
DOIs	https://doi.org/10.1212/wnl.53.3.642
Publication status	Published - Aug 11 1999
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

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Cite this

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title = "No association of alpha-2 macroglobulin gene five-nucleotide deletion with AD in Taiwan Chinese",

abstract = "The alpha-2 macroglobulin five-nucleotide deletion (A2M-2) allele frequency was not significantly higher in the AD group than the control group (0.062 versus 0.101, p > 0.1). The odds ratio for AD in individuals with the A2M-2 allele was 0.582 (95\% CI, 0.25 to 1.40). These results do not support the association between A2M-2 and AD in the Chinese population, although the allele frequency of A2M-2 is lower than that found in the Caucasian population. Therefore, A2M-2 might not be a significant risk factor of AD among Taiwan Chinese.",

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year = "1999",

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doi = "10.1212/wnl.53.3.642",

language = "English",

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TY - JOUR

T1 - No association of alpha-2 macroglobulin gene five-nucleotide deletion with AD in Taiwan Chinese

AU - Hu, C. J.

AU - Sung, S. M.

AU - Liu, H. C.

AU - Lee, K. Y.

AU - Hsu, W. C.

AU - Wong, W. K.

AU - Lee, C. C.

AU - Tsai, C. H.

AU - Chang, Jan Gowth

PY - 1999/8/11

Y1 - 1999/8/11

N2 - The alpha-2 macroglobulin five-nucleotide deletion (A2M-2) allele frequency was not significantly higher in the AD group than the control group (0.062 versus 0.101, p > 0.1). The odds ratio for AD in individuals with the A2M-2 allele was 0.582 (95% CI, 0.25 to 1.40). These results do not support the association between A2M-2 and AD in the Chinese population, although the allele frequency of A2M-2 is lower than that found in the Caucasian population. Therefore, A2M-2 might not be a significant risk factor of AD among Taiwan Chinese.

AB - The alpha-2 macroglobulin five-nucleotide deletion (A2M-2) allele frequency was not significantly higher in the AD group than the control group (0.062 versus 0.101, p > 0.1). The odds ratio for AD in individuals with the A2M-2 allele was 0.582 (95% CI, 0.25 to 1.40). These results do not support the association between A2M-2 and AD in the Chinese population, although the allele frequency of A2M-2 is lower than that found in the Caucasian population. Therefore, A2M-2 might not be a significant risk factor of AD among Taiwan Chinese.

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AN - SCOPUS:0033546616

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VL - 53

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EP - 643

JO - Neurology

JF - Neurology

IS - 3

ER -

No association of alpha-2 macroglobulin gene five-nucleotide deletion with AD in Taiwan Chinese

Abstract

ASJC Scopus subject areas

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