No association of alpha-2 macroglobulin gene five-nucleotide deletion with AD in Taiwan Chinese

C. J. Hu; S. M. Sung; H. C. Liu; K. Y. Lee; W. C. Hsu; W. K. Wong; C. C. Lee; C. H. Tsai; Jan Gowth Chang

doi:10.1212/wnl.53.3.642

No association of alpha-2 macroglobulin gene five-nucleotide deletion with AD in Taiwan Chinese

C. J. Hu, S. M. Sung, H. C. Liu, K. Y. Lee, W. C. Hsu, W. K. Wong, C. C. Lee, C. H. Tsai, Jan Gowth Chang

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

The alpha-2 macroglobulin five-nucleotide deletion (A2M-2) allele frequency was not significantly higher in the AD group than the control group (0.062 versus 0.101, p > 0.1). The odds ratio for AD in individuals with the A2M-2 allele was 0.582 (95% CI, 0.25 to 1.40). These results do not support the association between A2M-2 and AD in the Chinese population, although the allele frequency of A2M-2 is lower than that found in the Caucasian population. Therefore, A2M-2 might not be a significant risk factor of AD among Taiwan Chinese.

Original language	English
Pages (from-to)	642-643
Number of pages	2
Journal	Neurology
Volume	53
Issue number	3
DOIs	https://doi.org/10.1212/wnl.53.3.642
Publication status	Published - Aug 11 1999
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

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title = "No association of alpha-2 macroglobulin gene five-nucleotide deletion with AD in Taiwan Chinese",

abstract = "The alpha-2 macroglobulin five-nucleotide deletion (A2M-2) allele frequency was not significantly higher in the AD group than the control group (0.062 versus 0.101, p > 0.1). The odds ratio for AD in individuals with the A2M-2 allele was 0.582 (95% CI, 0.25 to 1.40). These results do not support the association between A2M-2 and AD in the Chinese population, although the allele frequency of A2M-2 is lower than that found in the Caucasian population. Therefore, A2M-2 might not be a significant risk factor of AD among Taiwan Chinese.",

author = "Hu, {C. J.} and Sung, {S. M.} and Liu, {H. C.} and Lee, {K. Y.} and Hsu, {W. C.} and Wong, {W. K.} and Lee, {C. C.} and Tsai, {C. H.} and Chang, {Jan Gowth}",

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doi = "10.1212/wnl.53.3.642",

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T1 - No association of alpha-2 macroglobulin gene five-nucleotide deletion with AD in Taiwan Chinese

AU - Hu, C. J.

AU - Sung, S. M.

AU - Liu, H. C.

AU - Lee, K. Y.

AU - Hsu, W. C.

AU - Wong, W. K.

AU - Lee, C. C.

AU - Tsai, C. H.

AU - Chang, Jan Gowth

PY - 1999/8/11

Y1 - 1999/8/11

N2 - The alpha-2 macroglobulin five-nucleotide deletion (A2M-2) allele frequency was not significantly higher in the AD group than the control group (0.062 versus 0.101, p > 0.1). The odds ratio for AD in individuals with the A2M-2 allele was 0.582 (95% CI, 0.25 to 1.40). These results do not support the association between A2M-2 and AD in the Chinese population, although the allele frequency of A2M-2 is lower than that found in the Caucasian population. Therefore, A2M-2 might not be a significant risk factor of AD among Taiwan Chinese.

AB - The alpha-2 macroglobulin five-nucleotide deletion (A2M-2) allele frequency was not significantly higher in the AD group than the control group (0.062 versus 0.101, p > 0.1). The odds ratio for AD in individuals with the A2M-2 allele was 0.582 (95% CI, 0.25 to 1.40). These results do not support the association between A2M-2 and AD in the Chinese population, although the allele frequency of A2M-2 is lower than that found in the Caucasian population. Therefore, A2M-2 might not be a significant risk factor of AD among Taiwan Chinese.

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No association of alpha-2 macroglobulin gene five-nucleotide deletion with AD in Taiwan Chinese

Abstract

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