Nitric oxide and upper airway

H. W. Wang, W. Y. Su

Research output: Contribution to journalArticlepeer-review


Nitric oxide is formed in cells by the enzyme known as NO synthase (NOS). Three isoforms of NOS are now known to exist. They are nNOS, iNOS and eNOS. In normal persons, a large NO production takes place in the epithelium of paranasal sinuses and this NO contributes considerably to the levels of NO found in nasally exhaled air. The high local NO concentrations in nasal airways and the sinuses may help to protect the airway against airborne infectious agent. Thus, airborne NO may represent first line of defence in the airways, possible acting on pathogens, even before they reach the mucosa. On the other hand, inhaled endogenous NO, derived from the upper airway, may be involved in regulation of pulmonary function in human.

Original languageEnglish
Pages (from-to)363-367
Number of pages5
JournalJournal of the Otolaryngological Society of the Republic of China
Issue number4
Publication statusPublished - 1998
Externally publishedYes


  • Nitric oxide
  • Upper airway

ASJC Scopus subject areas

  • Otorhinolaryngology


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