Nicotinuric acid: A potential marker of metabolic syndrome through a metabolomics-based approach

Chun Feng Huang, Mei Ling Cheng, Chun Ming Fan, Chuang Ye Hong, Ming Shi Shiao

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

OBJECTIVE - Metabolic syndrome is a multiplex disorder and puts patients on the road to type 2 diabetes and atherosclerotic cardiovascular diseases. However, a surrogate biomarker in plasma or urine in fully re flecting features of metabolic syndrome has not been explored. RESEARCH DESIGN AND METHODS - Urine metabolomics has potential utility in metabolic pro filing because urine metabolites analysis re flects global out flux of metabolic change. Accordingly, we collected data on subjects (n = 99) with overweight, dyslipidemia, hypertension or impaired glucose tolerance and took a metabolomics approach to analyze the metabolites of urine revealed in metabolic syndrome by high-performance liquid chromatography- time-of- flight mass spectrometry and elicit potential biomarkers to picture metabolic syndrome. RESULTS - Our results revealed that the urine nicotinuric acid value of subjects with diabetes (HbA1c ≥6.5% or those receiving diabetes medications) (n = 25) was higher than subjects without diabetes (n = 37) (221 ± 31 vs. 152 ± 13 X 103 mAU, P = 0.0268). Moreover, urinary nicotinuric acid level was positively correlated with body mass index, blood pressure, total cholesterol, low-density lipoprotein cholesterol, triacylglycerol and high sensitivity C-reactive protein, but negatively correlated with high-density lipoprotein cholesterol. CONCLUSIONS - This is the first study, to our knowledge, to propose that nicotinuric acid represents an important pathogenicmechanism in process from metabolic syndrome to diabetes and atherosclerotic cardiovascular disease.

Original languageEnglish
Pages (from-to)1729-1731
Number of pages3
JournalDiabetes Care
Volume36
Issue number6
DOIs
Publication statusPublished - Jun 2013

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

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