New Trichothecenes Isolated from the Marine Algicolous Fungus Trichoderma brevicompactum

Safwan Safwan; Shih Wei Wang; George Hsiao; Sui Wen Hsiao; Su Jung Hsu; Tzong Huei Lee; Ching Kuo Lee

doi:10.3390/md20020080

New Trichothecenes Isolated from the Marine Algicolous Fungus Trichoderma brevicompactum

Safwan Safwan, Shih Wei Wang, George Hsiao, Sui Wen Hsiao, Su Jung Hsu, Tzong Huei Lee, Ching Kuo Lee

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Eight trichothecenes, including four new compounds 1–4 and four known entities 5–8, together with one known cyclonerane (9) were isolated from the solid-state fermentation of Trichoderma brevicompactum NTU439 isolated from the marine alga Mastophora rosea. The structures of 1–9 were determined by 1D/2D NMR (nuclear magnetic resonance), MS (mass spectrometry), and IR (infrared spectroscopy) spectroscopic data. All of the compounds were evaluated for cytotoxic activity against HCT-116, PC-3, and SK-Hep-1 cancer cells by the SRB assay, and compound 8 showed promising cytotoxic activity against all three cancer cell lines with the IC₅₀ values of 3.3 ± 0.3, 5.3 ± 0.3, and 1.8 ± 0.8 µM, respectively. Compounds 1–2, 4–6, and 7–8 potently inhibited LPS-induced NO production, and compounds 5 and 8 showed markedly inhibited gelatinolysis of MMP-9 in S1 protein-stimulated THP-1 monocytes.

Original language	English
Article number	80
Journal	Marine Drugs
Volume	20
Issue number	2
DOIs	https://doi.org/10.3390/md20020080
Publication status	Published - Feb 2022

Keywords

Cytotoxic activities
Endophytic fungus
Marine alga
Trichoderma brevicompactum
Trichothecenes

ASJC Scopus subject areas

Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/md20020080

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title = "New Trichothecenes Isolated from the Marine Algicolous Fungus Trichoderma brevicompactum",

abstract = "Eight trichothecenes, including four new compounds 1–4 and four known entities 5–8, together with one known cyclonerane (9) were isolated from the solid-state fermentation of Trichoderma brevicompactum NTU439 isolated from the marine alga Mastophora rosea. The structures of 1–9 were determined by 1D/2D NMR (nuclear magnetic resonance), MS (mass spectrometry), and IR (infrared spectroscopy) spectroscopic data. All of the compounds were evaluated for cytotoxic activity against HCT-116, PC-3, and SK-Hep-1 cancer cells by the SRB assay, and compound 8 showed promising cytotoxic activity against all three cancer cell lines with the IC50 values of 3.3 ± 0.3, 5.3 ± 0.3, and 1.8 ± 0.8 µM, respectively. Compounds 1–2, 4–6, and 7–8 potently inhibited LPS-induced NO production, and compounds 5 and 8 showed markedly inhibited gelatinolysis of MMP-9 in S1 protein-stimulated THP-1 monocytes.",

keywords = "Cytotoxic activities, Endophytic fungus, Marine alga, Trichoderma brevicompactum, Trichothecenes",

author = "Safwan Safwan and Wang, {Shih Wei} and George Hsiao and Hsiao, {Sui Wen} and Hsu, {Su Jung} and Lee, {Tzong Huei} and Lee, {Ching Kuo}",

note = "Funding Information: Funding: This research was funded by Ministry of Science and Technology of the Republic of China (Taiwan) (MOST 107-2320-B-038-019-MY3). Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

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volume = "20",

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AU - Safwan, Safwan

AU - Wang, Shih Wei

AU - Hsiao, George

AU - Hsiao, Sui Wen

AU - Hsu, Su Jung

AU - Lee, Tzong Huei

AU - Lee, Ching Kuo

N1 - Funding Information: Funding: This research was funded by Ministry of Science and Technology of the Republic of China (Taiwan) (MOST 107-2320-B-038-019-MY3). Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

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N2 - Eight trichothecenes, including four new compounds 1–4 and four known entities 5–8, together with one known cyclonerane (9) were isolated from the solid-state fermentation of Trichoderma brevicompactum NTU439 isolated from the marine alga Mastophora rosea. The structures of 1–9 were determined by 1D/2D NMR (nuclear magnetic resonance), MS (mass spectrometry), and IR (infrared spectroscopy) spectroscopic data. All of the compounds were evaluated for cytotoxic activity against HCT-116, PC-3, and SK-Hep-1 cancer cells by the SRB assay, and compound 8 showed promising cytotoxic activity against all three cancer cell lines with the IC50 values of 3.3 ± 0.3, 5.3 ± 0.3, and 1.8 ± 0.8 µM, respectively. Compounds 1–2, 4–6, and 7–8 potently inhibited LPS-induced NO production, and compounds 5 and 8 showed markedly inhibited gelatinolysis of MMP-9 in S1 protein-stimulated THP-1 monocytes.

AB - Eight trichothecenes, including four new compounds 1–4 and four known entities 5–8, together with one known cyclonerane (9) were isolated from the solid-state fermentation of Trichoderma brevicompactum NTU439 isolated from the marine alga Mastophora rosea. The structures of 1–9 were determined by 1D/2D NMR (nuclear magnetic resonance), MS (mass spectrometry), and IR (infrared spectroscopy) spectroscopic data. All of the compounds were evaluated for cytotoxic activity against HCT-116, PC-3, and SK-Hep-1 cancer cells by the SRB assay, and compound 8 showed promising cytotoxic activity against all three cancer cell lines with the IC50 values of 3.3 ± 0.3, 5.3 ± 0.3, and 1.8 ± 0.8 µM, respectively. Compounds 1–2, 4–6, and 7–8 potently inhibited LPS-induced NO production, and compounds 5 and 8 showed markedly inhibited gelatinolysis of MMP-9 in S1 protein-stimulated THP-1 monocytes.

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KW - Trichothecenes

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New Trichothecenes Isolated from the Marine Algicolous Fungus Trichoderma brevicompactum

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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