New secondary metabolites from an endophytic fungus in porodaedalea pini

Shuen Shin Yang, Ming Jen Cheng, Hing Yuen Chan, Sung Yuan Hsieh, Ho Cheng Wu, Gwo Fang Yuan, Chu Hung Lin, Hsun Shuo Chang, Ih Sheng Chen

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Eight benzenoids including three new phenols, piniphenols A–C (1–3), along with five known compounds, 4-vinylphenol (4) and 4-hydroxybenzaldehyde (5), 2-methoxy-2-(4'-hydroxyphenyl)ethanol (6), 2,3-dihydroxypropyl acetate (7), and phenol (8) were isolated from ethyl acetate layer of liquid fermentation with Porodaedalea pini (Hymenochaetaceae) BCRC 35384. All structures were established by spectral analysis and comparison with the literature data. Of these isolates, 1 showed moderate NO inhibitory activity with an IC50 value of 60.0 μM. Compound 1 also showed the androgen receptor (AR) antagonism with the IC50 value of 0.42 μM. To the best of our knowledge, this is the first report on benzenoid metabolites from the genus Porodaedalea.

Original languageEnglish
Pages (from-to)251-257
Number of pages7
JournalRecords of Natural Products
Issue number3
Publication statusPublished - 2017
Externally publishedYes


  • Androgen antagonism
  • Benzenoids
  • Fungus
  • NO inhibitory activity
  • Porodaedalea pini

ASJC Scopus subject areas

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Organic Chemistry


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