New secondary metabolites from an endophytic fungus in porodaedalea pini

Shuen Shin Yang; Ming Jen Cheng; Hing Yuen Chan; Sung Yuan Hsieh; Ho Cheng Wu; Gwo Fang Yuan; Chu Hung Lin; Hsun Shuo Chang; Ih Sheng Chen

New secondary metabolites from an endophytic fungus in porodaedalea pini

Shuen Shin Yang, Ming Jen Cheng, Hing Yuen Chan, Sung Yuan Hsieh, Ho Cheng Wu, Gwo Fang Yuan, Chu Hung Lin, Hsun Shuo Chang, Ih Sheng Chen

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Eight benzenoids including three new phenols, piniphenols A–C (1–3), along with five known compounds, 4-vinylphenol (4) and 4-hydroxybenzaldehyde (5), 2-methoxy-2-(4'-hydroxyphenyl)ethanol (6), 2,3-dihydroxypropyl acetate (7), and phenol (8) were isolated from ethyl acetate layer of liquid fermentation with Porodaedalea pini (Hymenochaetaceae) BCRC 35384. All structures were established by spectral analysis and comparison with the literature data. Of these isolates, 1 showed moderate NO inhibitory activity with an IC₅₀ value of 60.0 μM. Compound 1 also showed the androgen receptor (AR) antagonism with the IC₅₀ value of 0.42 μM. To the best of our knowledge, this is the first report on benzenoid metabolites from the genus Porodaedalea.

Original language	English
Pages (from-to)	251-257
Number of pages	7
Journal	Records of Natural Products
Volume	11
Issue number	3
Publication status	Published - 2017
Externally published	Yes

Keywords

Androgen antagonism
Benzenoids
Fungus
NO inhibitory activity
Porodaedalea pini

ASJC Scopus subject areas

Pharmacology
Plant Science
Drug Discovery
Organic Chemistry

Cite this

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title = "New secondary metabolites from an endophytic fungus in porodaedalea pini",

abstract = "Eight benzenoids including three new phenols, piniphenols A–C (1–3), along with five known compounds, 4-vinylphenol (4) and 4-hydroxybenzaldehyde (5), 2-methoxy-2-(4'-hydroxyphenyl)ethanol (6), 2,3-dihydroxypropyl acetate (7), and phenol (8) were isolated from ethyl acetate layer of liquid fermentation with Porodaedalea pini (Hymenochaetaceae) BCRC 35384. All structures were established by spectral analysis and comparison with the literature data. Of these isolates, 1 showed moderate NO inhibitory activity with an IC50 value of 60.0 μM. Compound 1 also showed the androgen receptor (AR) antagonism with the IC50 value of 0.42 μM. To the best of our knowledge, this is the first report on benzenoid metabolites from the genus Porodaedalea.",

keywords = "Androgen antagonism, Benzenoids, Fungus, NO inhibitory activity, Porodaedalea pini",

author = "Yang, {Shuen Shin} and Cheng, {Ming Jen} and Chan, {Hing Yuen} and Hsieh, {Sung Yuan} and Wu, {Ho Cheng} and Yuan, {Gwo Fang} and Lin, {Chu Hung} and Chang, {Hsun Shuo} and Chen, {Ih Sheng}",

note = "Funding Information: This work kindly supported by the Ministry of Economic Affairs. Taiwan, ROC to Food Industry Reaserch & Development Institute (FIRDI). Publisher Copyright: {\textcopyright} 2017 ACG Publications. All rights reserved.",

year = "2017",

language = "English",

volume = "11",

pages = "251--257",

journal = "Records of Natural Products",

issn = "1307-6167",

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T1 - New secondary metabolites from an endophytic fungus in porodaedalea pini

AU - Yang, Shuen Shin

AU - Cheng, Ming Jen

AU - Chan, Hing Yuen

AU - Hsieh, Sung Yuan

AU - Wu, Ho Cheng

AU - Yuan, Gwo Fang

AU - Lin, Chu Hung

AU - Chang, Hsun Shuo

AU - Chen, Ih Sheng

N1 - Funding Information: This work kindly supported by the Ministry of Economic Affairs. Taiwan, ROC to Food Industry Reaserch & Development Institute (FIRDI). Publisher Copyright: © 2017 ACG Publications. All rights reserved.

PY - 2017

Y1 - 2017

N2 - Eight benzenoids including three new phenols, piniphenols A–C (1–3), along with five known compounds, 4-vinylphenol (4) and 4-hydroxybenzaldehyde (5), 2-methoxy-2-(4'-hydroxyphenyl)ethanol (6), 2,3-dihydroxypropyl acetate (7), and phenol (8) were isolated from ethyl acetate layer of liquid fermentation with Porodaedalea pini (Hymenochaetaceae) BCRC 35384. All structures were established by spectral analysis and comparison with the literature data. Of these isolates, 1 showed moderate NO inhibitory activity with an IC50 value of 60.0 μM. Compound 1 also showed the androgen receptor (AR) antagonism with the IC50 value of 0.42 μM. To the best of our knowledge, this is the first report on benzenoid metabolites from the genus Porodaedalea.

AB - Eight benzenoids including three new phenols, piniphenols A–C (1–3), along with five known compounds, 4-vinylphenol (4) and 4-hydroxybenzaldehyde (5), 2-methoxy-2-(4'-hydroxyphenyl)ethanol (6), 2,3-dihydroxypropyl acetate (7), and phenol (8) were isolated from ethyl acetate layer of liquid fermentation with Porodaedalea pini (Hymenochaetaceae) BCRC 35384. All structures were established by spectral analysis and comparison with the literature data. Of these isolates, 1 showed moderate NO inhibitory activity with an IC50 value of 60.0 μM. Compound 1 also showed the androgen receptor (AR) antagonism with the IC50 value of 0.42 μM. To the best of our knowledge, this is the first report on benzenoid metabolites from the genus Porodaedalea.

KW - Androgen antagonism

KW - Benzenoids

KW - Fungus

KW - NO inhibitory activity

KW - Porodaedalea pini

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M3 - Article

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SN - 1307-6167

VL - 11

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EP - 257

JO - Records of Natural Products

JF - Records of Natural Products

IS - 3

ER -

New secondary metabolites from an endophytic fungus in porodaedalea pini

Abstract

Keywords

ASJC Scopus subject areas

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