New insights into oral squamous cell carcinoma: From clinical aspects to molecular tumorigenesis

Shang Hung Chen, Sheng Yen Hsiao, Kwang Yu Chang, Jang Yang Chang

Research output: Contribution to journalReview articlepeer-review

41 Citations (Scopus)


Oral squamous cell carcinoma (SCC) is a prevalent malignant disease worldwide, especially so in Taiwan. Early-or even preclinical-stage detection is critical for reducing morbidity and mortality from oral SCC. Epidemiological and genome association studies are useful for identifying clinicopathological risk factors for preventive, diagnostic, and therapeutic approaches of oral SCC. For advanced oral SCC, effective treatments are critical to prolonging survival and enhancing quality of life. As oral SCC is characteristic of regional invasion with lymph node metastases, understanding the aggressive features of oral SCC, particularly in lymphangiogenesis, is essential for de-termining effective treatments. Emerging evidence has demonstrated that the tumor microenviron-ment (TME) plays a pivotal role in tumor growth, invasion, and metastases. Recent clinical successes in immune checkpoint inhibitors either alone or combined with chemotherapy have also supported the therapeutic value of immunotherapy in oral SCC. This review summarizes critical advances in basic knowledge of oral SCC from the perspective of clinicopathological risk factors, molecular tu-morigenesis, and the TME. We also highlight our recent investigations on the microbiome, genome association studies, lymphangiogenesis, and immunomodulation in oral SCC. This review may provide new insights for oral SCC treatment by systematically interpreting emerging evidence from various preclinical and clinical studies.

Original languageEnglish
Article number2252
Pages (from-to)1-21
Number of pages21
JournalInternational journal of molecular sciences
Issue number5
Publication statusPublished - Mar 1 2021
Externally publishedYes


  • IL-1β
  • Lymphangiogenesis
  • Microbiota
  • MicroRNA
  • Mitochon-drion
  • Oral squamous cell carcinoma
  • Tumor microenvironment

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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