New cytotoxic briaran diterpenes from the formosan gorgonian Briareum sp.

Jyh Horng Sheu; Ping Jyun Sung; Li Huei Huang; Shu Fang Lee; Tzuhua Wu; Bih Yuan Chang; Chang Yih Duh; Lee Shing Fang; Keryea Soong; Tsong Jen Lee

doi:10.1021/np960218s

New cytotoxic briaran diterpenes from the formosan gorgonian Briareum sp.

Jyh Horng Sheu, Ping Jyun Sung, Li Huei Huang, Shu Fang Lee, Tzuhua Wu, Bih Yuan Chang, Chang Yih Duh, Lee Shing Fang, Keryea Soong, Tsong Jen Lee

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

Three new briaran diterpenes, 2β-acetoxy-2-(debutyryloxy)stecholide E (3), 9-deacetylstylatulide lactone (4), and 4β-acetoxy-9-deacetylstylatulide lactone (5), and two known diterpenes, brianthein W (1) and 9- deacetylbriareolide H (2), have been isolated from a Briareum sp. of gorgonian. The structures and relative stereochemistry of these compounds were determined by spectroscopic and chemical methods. Diterpenes 2-4 and the corresponding 9-acetyl derivatives 6, 7, and 12 exhibited cytotoxicity toward various cancer cell lines.

Original language	English
Pages (from-to)	935-938
Number of pages	4
Journal	Journal of Natural Products
Volume	59
Issue number	10
DOIs	https://doi.org/10.1021/np960218s
Publication status	Published - Oct 1 1996

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/np960218s

Cite this

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title = "New cytotoxic briaran diterpenes from the formosan gorgonian Briareum sp.",

abstract = "Three new briaran diterpenes, 2β-acetoxy-2-(debutyryloxy)stecholide E (3), 9-deacetylstylatulide lactone (4), and 4β-acetoxy-9-deacetylstylatulide lactone (5), and two known diterpenes, brianthein W (1) and 9- deacetylbriareolide H (2), have been isolated from a Briareum sp. of gorgonian. The structures and relative stereochemistry of these compounds were determined by spectroscopic and chemical methods. Diterpenes 2-4 and the corresponding 9-acetyl derivatives 6, 7, and 12 exhibited cytotoxicity toward various cancer cell lines.",

author = "Sheu, {Jyh Horng} and Sung, {Ping Jyun} and Huang, {Li Huei} and Lee, {Shu Fang} and Tzuhua Wu and Chang, {Bih Yuan} and Duh, {Chang Yih} and Fang, {Lee Shing} and Keryea Soong and Lee, {Tsong Jen}",

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doi = "10.1021/np960218s",

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T1 - New cytotoxic briaran diterpenes from the formosan gorgonian Briareum sp.

AU - Sheu, Jyh Horng

AU - Sung, Ping Jyun

AU - Huang, Li Huei

AU - Lee, Shu Fang

AU - Wu, Tzuhua

AU - Chang, Bih Yuan

AU - Duh, Chang Yih

AU - Fang, Lee Shing

AU - Soong, Keryea

AU - Lee, Tsong Jen

PY - 1996/10/1

Y1 - 1996/10/1

N2 - Three new briaran diterpenes, 2β-acetoxy-2-(debutyryloxy)stecholide E (3), 9-deacetylstylatulide lactone (4), and 4β-acetoxy-9-deacetylstylatulide lactone (5), and two known diterpenes, brianthein W (1) and 9- deacetylbriareolide H (2), have been isolated from a Briareum sp. of gorgonian. The structures and relative stereochemistry of these compounds were determined by spectroscopic and chemical methods. Diterpenes 2-4 and the corresponding 9-acetyl derivatives 6, 7, and 12 exhibited cytotoxicity toward various cancer cell lines.

AB - Three new briaran diterpenes, 2β-acetoxy-2-(debutyryloxy)stecholide E (3), 9-deacetylstylatulide lactone (4), and 4β-acetoxy-9-deacetylstylatulide lactone (5), and two known diterpenes, brianthein W (1) and 9- deacetylbriareolide H (2), have been isolated from a Briareum sp. of gorgonian. The structures and relative stereochemistry of these compounds were determined by spectroscopic and chemical methods. Diterpenes 2-4 and the corresponding 9-acetyl derivatives 6, 7, and 12 exhibited cytotoxicity toward various cancer cell lines.

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New cytotoxic briaran diterpenes from the formosan gorgonian Briareum sp.

Abstract

ASJC Scopus subject areas

UN SDGs

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