New abietane-type diterpenoids from the bark of cryptomeria japonica

Chi I. Chang; Jih Jung Chen; Chin Hsu; Cheng Chi Chen; Wei Yi Cheng; Sheng Yang Wang; Ching Kuo Lee; Ming Jen Cheng; Yueh Hsiung Kuo

doi:10.1177/1934578X1901400125

New abietane-type diterpenoids from the bark of cryptomeria japonica

Chi I. Chang, Jih Jung Chen, Chin Hsu, Cheng Chi Chen, Wei Yi Cheng, Sheng Yang Wang, Ching Kuo Lee, Ming Jen Cheng, Yueh Hsiung Kuo

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Two new abietane-type diterpenoids, 15-hydroxy-12-O-methylsugiol (1) and 2?-hydroxy-12-O-methylsugiol (2) were isolated from the methanol extract of the bark of Cryptomeria japonica. Their structures were elucidated on the basis of spectroscopic analysis and comparison of NMR data with those of known analogues. Compounds 2 showed 13.5% inhibition towards xanthine oxidase enzyme at the concentration of 75 μM.

Original language	English
Pages (from-to)	97-100
Number of pages	4
Journal	Natural Product Communications
Volume	14
Issue number	1
DOIs	https://doi.org/10.1177/1934578X1901400125
Publication status	Published - Jan 1 2019

Keywords

Abietane
Cryptomeria japonica
Cupressaceae
Diterpenoid
Traditional herbal medicine

ASJC Scopus subject areas

Pharmacology
Drug Discovery
Plant Science
Complementary and alternative medicine

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10.1177/1934578X1901400125

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abstract = "Two new abietane-type diterpenoids, 15-hydroxy-12-O-methylsugiol (1) and 2?-hydroxy-12-O-methylsugiol (2) were isolated from the methanol extract of the bark of Cryptomeria japonica. Their structures were elucidated on the basis of spectroscopic analysis and comparison of NMR data with those of known analogues. Compounds 2 showed 13.5% inhibition towards xanthine oxidase enzyme at the concentration of 75 μM.",

keywords = "Abietane, Cryptomeria japonica, Cupressaceae, Diterpenoid, Traditional herbal medicine",

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doi = "10.1177/1934578X1901400125",

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T1 - New abietane-type diterpenoids from the bark of cryptomeria japonica

AU - Chang, Chi I.

AU - Chen, Jih Jung

AU - Hsu, Chin

AU - Chen, Cheng Chi

AU - Cheng, Wei Yi

AU - Wang, Sheng Yang

AU - Lee, Ching Kuo

AU - Cheng, Ming Jen

AU - Kuo, Yueh Hsiung

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Two new abietane-type diterpenoids, 15-hydroxy-12-O-methylsugiol (1) and 2?-hydroxy-12-O-methylsugiol (2) were isolated from the methanol extract of the bark of Cryptomeria japonica. Their structures were elucidated on the basis of spectroscopic analysis and comparison of NMR data with those of known analogues. Compounds 2 showed 13.5% inhibition towards xanthine oxidase enzyme at the concentration of 75 μM.

AB - Two new abietane-type diterpenoids, 15-hydroxy-12-O-methylsugiol (1) and 2?-hydroxy-12-O-methylsugiol (2) were isolated from the methanol extract of the bark of Cryptomeria japonica. Their structures were elucidated on the basis of spectroscopic analysis and comparison of NMR data with those of known analogues. Compounds 2 showed 13.5% inhibition towards xanthine oxidase enzyme at the concentration of 75 μM.

KW - Abietane

KW - Cryptomeria japonica

KW - Cupressaceae

KW - Diterpenoid

KW - Traditional herbal medicine

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New abietane-type diterpenoids from the bark of cryptomeria japonica

Abstract

Keywords

ASJC Scopus subject areas

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