Neuroprotective effects of platonin, a therapeutic immunomodulating medicine, on traumatic brain injury in mice after controlled cortical impact

Ting Lin Yen, Chao Chien Chang, Chi Li Chung, Wen Chin Ko, Chih Hao Yang, Cheng Ying Hsieh

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Traumatic brain injury (TBI) is one of the leading causes of mortality worldwide and leads to persistent cognitive, sensory, motor dysfunction, and emotional disorders. TBI-caused primary injury results in structural damage to brain tissues. Following the primary injury, secondary injuries which are accompanied by neuroinflammation, microglial activation, and additional cell death subsequently occur. Platonin, a cyanine photosensitizing dye, has been used to treat trauma, ulcers, and some types of acute inflammation. In the present study, the neuroprotective effects of platonin against TBI were explored in a controlled cortical impact (CCI) injury model in mice. Treatment with platonin (200 μg/kg) significantly reduced the neurological severity score, general locomotor activity, and anxiety-related behavior, and improved the rotarod performance of CCI-injured mice. In addition, platonin reduced lesion volumes, the expression of cleaved caspase-3, and microglial activation in TBI-insulted brains. Platonin also suppressed messenger (m)RNA levels of caspase-3, caspase-1, cyclooxygenase-2, tumor necrosis factor-α, interleukin-6, and interleukin-1β. On the other hand, free radical production after TBI was obviously attenuated in platonin-treated mice. Treatment with platonin exhibited prominent neuroprotective properties against TBI in a CCI mouse model through its anti-inflammatory, anti-apoptotic, and anti-free radical capabilities. This evidence collectively indicates that platonin may be a potential therapeutic medicine for use with TBIs.

Original languageEnglish
Article number1100
JournalInternational Journal of Molecular Sciences
Issue number4
Publication statusPublished - Apr 6 2018


  • Free radical
  • Microglial activation
  • Neuroinflammation
  • Platonin
  • Traumatic brain injury
  • Thiazoles/therapeutic use
  • Microglia/metabolism
  • Neuroprotective Agents/therapeutic use
  • Interleukins/genetics
  • Cerebral Cortex/metabolism
  • Mice, Inbred C57BL
  • Male
  • Brain Injuries, Traumatic/drug therapy
  • Tumor Necrosis Factor-alpha/genetics
  • Cyclooxygenase 2/genetics
  • Anti-Inflammatory Agents/therapeutic use
  • Locomotion
  • Animals
  • Caspases/genetics
  • Mice
  • Hand Strength

ASJC Scopus subject areas

  • Molecular Biology
  • Spectroscopy
  • Catalysis
  • Inorganic Chemistry
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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