Neuropathology changed by 3- and 6-months low-level PM2.5 inhalation exposure in spontaneously hypertensive rats

Hsiao-Chi Chuang; Hsin-Chang Chen; Pei-Jui Chai; Ho-Tang Liao; Chang-Fu Wu; Chia-Ling Chen; Ming-Kai Jhan; Hui-I Hsieh; Kuen-Yuh Wu; Ta-Fu Chen; Tsun-Jen Cheng

doi:10.1186/s12989-020-00388-6

Neuropathology changed by 3- and 6-months low-level PM2.5 inhalation exposure in spontaneously hypertensive rats

Hsiao-Chi Chuang
, Hsin-Chang Chen
, Pei-Jui Chai
, Ho-Tang Liao
, Chang-Fu Wu
, Chia-Ling Chen
, Ming-Kai Jhan
, Hui-I Hsieh
, Kuen-Yuh Wu
, Ta-Fu Chen
, Tsun-Jen Cheng

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Epidemiological evidence has linked fine particulate matter (PM2.5) to neurodegenerative diseases; however, the toxicological evidence remains unclear. The objective of this study was to investigate the effects of PM2.5 on neuropathophysiology in a hypertensive animal model. We examined behavioral alterations (Morris water maze), lipid peroxidation (malondialdehyde (MDA)), tau and autophagy expressions, neuron death, and caspase-3 levels after 3 and 6 months of whole-body exposure to urban PM2.5 in spontaneously hypertensive (SH) rats.

Original language	English
Journal	Particle and Fibre Toxicology
Volume	17
Issue number	1
DOIs	https://doi.org/10.1186/s12989-020-00388-6
Publication status	Published - 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 11 Sustainable Cities and Communities

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10.1186/s12989-020-00388-6

Neuropathology changed by 3- and 6-months low-level PM2.5 inhalation exposure in spontaneously hypertensive rats
Chuang, H.-C. (Contributor), Chen, H.-C. (Creator), Chai, P.-J. (Contributor), Liao, H.-T. (Contributor), Wu, C.-F. (Creator), Chen, C.-L. (Creator), Jhan, M.-K. (Creator), Hsieh, H.-I. (Contributor), Wu, K.-Y. (Creator), Chen, T.-F. (Creator) & Cheng, T.-J. (Contributor), Figshare, 2020
DOI: 10.6084/m9.figshare.c.5221075.v1, https://doi.org/10.6084%2Fm9.figshare.c.5221075.v1
Dataset
Additional file 1 of Neuropathology changed by 3- and 6-months low-level PM2.5 inhalation exposure in spontaneously hypertensive rats
Chai, P.-J. (Contributor), Chuang, H.-C. (Contributor), Jhan, M.-K. (Creator), Chen, H.-C. (Creator), Wu, C.-F. (Creator), Hsieh, H.-I. (Contributor), Cheng, T.-J. (Contributor), Liao, H.-T. (Contributor), Wu, K.-Y. (Creator), Chen, C.-L. (Creator) & Chen, T.-F. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.13294726.v1, https://doi.org/10.6084%2Fm9.figshare.13294726.v1
Dataset

Cite this

@article{108fd595bcfd449b9b601fc20cd79590,

title = "Neuropathology changed by 3- and 6-months low-level PM2.5 inhalation exposure in spontaneously hypertensive rats",

abstract = "Epidemiological evidence has linked fine particulate matter (PM2.5) to neurodegenerative diseases; however, the toxicological evidence remains unclear. The objective of this study was to investigate the effects of PM2.5 on neuropathophysiology in a hypertensive animal model. We examined behavioral alterations (Morris water maze), lipid peroxidation (malondialdehyde (MDA)), tau and autophagy expressions, neuron death, and caspase-3 levels after 3 and 6 months of whole-body exposure to urban PM2.5 in spontaneously hypertensive (SH) rats.",

author = "Hsiao-Chi Chuang and Hsin-Chang Chen and Pei-Jui Chai and Ho-Tang Liao and Chang-Fu Wu and Chia-Ling Chen and Ming-Kai Jhan and Hui-I Hsieh and Kuen-Yuh Wu and Ta-Fu Chen and Tsun-Jen Cheng",

year = "2020",

doi = "10.1186/s12989-020-00388-6",

language = "English",

volume = "17",

journal = "Particle and Fibre Toxicology",

issn = "1743-8977",

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TY - JOUR

T1 - Neuropathology changed by 3- and 6-months low-level PM2.5 inhalation exposure in spontaneously hypertensive rats

AU - Chuang, Hsiao-Chi

AU - Chen, Hsin-Chang

AU - Chai, Pei-Jui

AU - Liao, Ho-Tang

AU - Wu, Chang-Fu

AU - Chen, Chia-Ling

AU - Jhan, Ming-Kai

AU - Hsieh, Hui-I

AU - Wu, Kuen-Yuh

AU - Chen, Ta-Fu

AU - Cheng, Tsun-Jen

PY - 2020

Y1 - 2020

N2 - Epidemiological evidence has linked fine particulate matter (PM2.5) to neurodegenerative diseases; however, the toxicological evidence remains unclear. The objective of this study was to investigate the effects of PM2.5 on neuropathophysiology in a hypertensive animal model. We examined behavioral alterations (Morris water maze), lipid peroxidation (malondialdehyde (MDA)), tau and autophagy expressions, neuron death, and caspase-3 levels after 3 and 6 months of whole-body exposure to urban PM2.5 in spontaneously hypertensive (SH) rats.

AB - Epidemiological evidence has linked fine particulate matter (PM2.5) to neurodegenerative diseases; however, the toxicological evidence remains unclear. The objective of this study was to investigate the effects of PM2.5 on neuropathophysiology in a hypertensive animal model. We examined behavioral alterations (Morris water maze), lipid peroxidation (malondialdehyde (MDA)), tau and autophagy expressions, neuron death, and caspase-3 levels after 3 and 6 months of whole-body exposure to urban PM2.5 in spontaneously hypertensive (SH) rats.

U2 - 10.1186/s12989-020-00388-6

DO - 10.1186/s12989-020-00388-6

M3 - Article

SN - 1743-8977

VL - 17

JO - Particle and Fibre Toxicology

JF - Particle and Fibre Toxicology

IS - 1

ER -

Neuropathology changed by 3- and 6-months low-level PM2.5 inhalation exposure in spontaneously hypertensive rats

Abstract

UN SDGs

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Datasets

Neuropathology changed by 3- and 6-months low-level PM2.5 inhalation exposure in spontaneously hypertensive rats

Additional file 1 of Neuropathology changed by 3- and 6-months low-level PM2.5 inhalation exposure in spontaneously hypertensive rats

Cite this