Abstract
Epidemiological evidence has linked fine particulate matter (PM2.5) to neurodegenerative diseases; however, the toxicological evidence remains unclear. The objective of this study was to investigate the effects of PM2.5 on neuropathophysiology in a hypertensive animal model. We examined behavioral alterations (Morris water maze), lipid peroxidation (malondialdehyde (MDA)), tau and autophagy expressions, neuron death, and caspase-3 levels after 3 and 6 months of whole-body exposure to urban PM2.5 in spontaneously hypertensive (SH) rats.
| Original language | English |
|---|---|
| Journal | Particle and Fibre Toxicology |
| Volume | 17 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2020 |
Datasets
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Neuropathology changed by 3- and 6-months low-level PM2.5 inhalation exposure in spontaneously hypertensive rats
Chuang, H. (Contributor), Chen, H. (Creator), Chai, P. (Contributor), Liao, H. (Contributor), Wu, C. (Creator), Chen, C. (Creator), Jhan, M. (Creator), Hsieh, H. (Contributor), Wu, K. (Creator), Chen, T. (Creator) & Cheng, T. (Contributor), Figshare, 2020
DOI: 10.6084/m9.figshare.c.5221075.v1, https://doi.org/10.6084%2Fm9.figshare.c.5221075.v1
Dataset
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Additional file 1 of Neuropathology changed by 3- and 6-months low-level PM2.5 inhalation exposure in spontaneously hypertensive rats
Chai, P. (Contributor), Chuang, H. (Contributor), Jhan, M. (Creator), Chen, H. (Creator), Wu, C. (Creator), Hsieh, H. (Contributor), Cheng, T. (Contributor), Liao, H. (Contributor), Wu, K. (Creator), Chen, C. (Creator) & Chen, T. (Creator), Figshare, 2020
DOI: 10.6084/m9.figshare.13294726.v1, https://doi.org/10.6084%2Fm9.figshare.13294726.v1
Dataset