TY - JOUR
T1 - Nephrectomy type was not associated with a subsequent risk of coronary heart disease
T2 - A population-based study
AU - Chung, Shiu Dong
AU - Huang, Chao Yuan
AU - Wu, Sheng Tang
AU - Lin, Herng-Ching
AU - Huang, Chung-Chien
AU - Kao, Li Ting
N1 - Publisher Copyright:
© 2016 Chung et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Previous studies investigated the impacts of a partial nephrectomy (PN) or radical nephrectomy (RN) on cardiovascular events and death. However, the association between the type of nephrectomy (PN vs. RN) and cardiovascular disease is still equivocal. This retrospective cohort study aimed to compare the risk of coronary heart disease (CHD) between patients who underwent a PN and those who underwent an RN. We used data from the Taiwan Longitudinal Health Insurance Database 2005. In total, 60 patients who underwent a PN and 545 patients who underwent an RN were included. Each patient was tracked for 1-, 2-, 3-, and 5-year periods to identify those who were subsequently diagnosed with CHD. Cox proportional hazard regression analyses were used to calculate hazard ratios (HRs) for CHD during 1-, 2-, 3-, and 5-year follow-up periods between these two cohorts. For the 1-year follow-up period, the adjusted HR was 0.39 (95% CI: 0.05∼2.90, p = 0.355) for patients who underwent a PN compared to those who underwent an RN. Additionally, the adjusted HRs of CHD in patients who underwent a PN for 2-, 3-and 5-year follow-up periods were 1.40 (95% CI: 0.62∼3.16, p = 0.417), 1.09 (95% CI: 0.52∼2.31, p = 0.814), and 1.02 (95% CI: 0.48∼2.18, p = 0.961), respectively, compared to those who underwent an RN. We concluded that there was no significant difference in the risk of CHD between patients who underwent a PN and those who underwent an RN.
AB - Previous studies investigated the impacts of a partial nephrectomy (PN) or radical nephrectomy (RN) on cardiovascular events and death. However, the association between the type of nephrectomy (PN vs. RN) and cardiovascular disease is still equivocal. This retrospective cohort study aimed to compare the risk of coronary heart disease (CHD) between patients who underwent a PN and those who underwent an RN. We used data from the Taiwan Longitudinal Health Insurance Database 2005. In total, 60 patients who underwent a PN and 545 patients who underwent an RN were included. Each patient was tracked for 1-, 2-, 3-, and 5-year periods to identify those who were subsequently diagnosed with CHD. Cox proportional hazard regression analyses were used to calculate hazard ratios (HRs) for CHD during 1-, 2-, 3-, and 5-year follow-up periods between these two cohorts. For the 1-year follow-up period, the adjusted HR was 0.39 (95% CI: 0.05∼2.90, p = 0.355) for patients who underwent a PN compared to those who underwent an RN. Additionally, the adjusted HRs of CHD in patients who underwent a PN for 2-, 3-and 5-year follow-up periods were 1.40 (95% CI: 0.62∼3.16, p = 0.417), 1.09 (95% CI: 0.52∼2.31, p = 0.814), and 1.02 (95% CI: 0.48∼2.18, p = 0.961), respectively, compared to those who underwent an RN. We concluded that there was no significant difference in the risk of CHD between patients who underwent a PN and those who underwent an RN.
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U2 - 10.1371/journal.pone.0163253
DO - 10.1371/journal.pone.0163253
M3 - Article
C2 - 27636094
AN - SCOPUS:84992422474
SN - 1932-6203
VL - 11
JO - PLoS One
JF - PLoS One
IS - 9
M1 - e0163253
ER -
