Natural Cembrane Diterpenoids From the Soft Coral Sinularia querciformis

Yi Ying Wu; Chia Ching Hsieh; Chia Ying Li; Wen Huei Chang; Jih Jung Chen; Kuei Hung Lai; Zhi Hong Wen; Hsu Ming Chung

doi:10.1177/1934578X211059299

Natural Cembrane Diterpenoids From the Soft Coral Sinularia querciformis

Yi Ying Wu, Chia Ching Hsieh, Chia Ying Li, Wen Huei Chang, Jih Jung Chen, Kuei Hung Lai, Zhi Hong Wen, Hsu Ming Chung

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Chemical examination of Sinularia querciformis afforded one new cembranoid, querciformolide F (1), along with four known cembranoids, sinulariolone (2), granosolide A (3), querciformolide A (4), and sinulariolide (5). The structures of these compounds were determined by extensive spectroscopic (IR, ESIMS, ¹H NMR, and ¹³C NMR) analysis and by comparison with those previously reported in the literature. Compounds 2 to 4 were found to exhibit significant anti-inflammatory activity in lipopolysaccharide (LPS)-induced RAW264.7 mouse macrophages through attenuating the expression of the inducible nitric oxide synthase (iNOS) proteins.

Original language	English
Journal	Natural Product Communications
Volume	16
Issue number	11
DOIs	https://doi.org/10.1177/1934578X211059299
Publication status	Published - Nov 2021

Keywords

antiinflammatory
cembrane
diterpenoid
sinularia querciformis
soft coral

ASJC Scopus subject areas

Pharmacology
Drug Discovery
Plant Science
Complementary and alternative medicine

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10.1177/1934578X211059299

Cite this

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title = "Natural Cembrane Diterpenoids From the Soft Coral Sinularia querciformis",

abstract = "Chemical examination of Sinularia querciformis afforded one new cembranoid, querciformolide F (1), along with four known cembranoids, sinulariolone (2), granosolide A (3), querciformolide A (4), and sinulariolide (5). The structures of these compounds were determined by extensive spectroscopic (IR, ESIMS, 1H NMR, and 13C NMR) analysis and by comparison with those previously reported in the literature. Compounds 2 to 4 were found to exhibit significant anti-inflammatory activity in lipopolysaccharide (LPS)-induced RAW264.7 mouse macrophages through attenuating the expression of the inducible nitric oxide synthase (iNOS) proteins.",

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author = "Wu, {Yi Ying} and Hsieh, {Chia Ching} and Li, {Chia Ying} and Chang, {Wen Huei} and Chen, {Jih Jung} and Lai, {Kuei Hung} and Wen, {Zhi Hong} and Chung, {Hsu Ming}",

note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Ministry of Science and Technology, Taiwan (grant number MOST 110-2320-B-153 -001). Publisher Copyright: {\textcopyright} The Author(s) 2021.",

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doi = "10.1177/1934578X211059299",

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AU - Hsieh, Chia Ching

AU - Li, Chia Ying

AU - Chang, Wen Huei

AU - Chen, Jih Jung

AU - Lai, Kuei Hung

AU - Wen, Zhi Hong

AU - Chung, Hsu Ming

N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Ministry of Science and Technology, Taiwan (grant number MOST 110-2320-B-153 -001). Publisher Copyright: © The Author(s) 2021.

PY - 2021/11

Y1 - 2021/11

N2 - Chemical examination of Sinularia querciformis afforded one new cembranoid, querciformolide F (1), along with four known cembranoids, sinulariolone (2), granosolide A (3), querciformolide A (4), and sinulariolide (5). The structures of these compounds were determined by extensive spectroscopic (IR, ESIMS, 1H NMR, and 13C NMR) analysis and by comparison with those previously reported in the literature. Compounds 2 to 4 were found to exhibit significant anti-inflammatory activity in lipopolysaccharide (LPS)-induced RAW264.7 mouse macrophages through attenuating the expression of the inducible nitric oxide synthase (iNOS) proteins.

AB - Chemical examination of Sinularia querciformis afforded one new cembranoid, querciformolide F (1), along with four known cembranoids, sinulariolone (2), granosolide A (3), querciformolide A (4), and sinulariolide (5). The structures of these compounds were determined by extensive spectroscopic (IR, ESIMS, 1H NMR, and 13C NMR) analysis and by comparison with those previously reported in the literature. Compounds 2 to 4 were found to exhibit significant anti-inflammatory activity in lipopolysaccharide (LPS)-induced RAW264.7 mouse macrophages through attenuating the expression of the inducible nitric oxide synthase (iNOS) proteins.

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KW - cembrane

KW - diterpenoid

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Natural Cembrane Diterpenoids From the Soft Coral Sinularia querciformis

Abstract

Keywords

ASJC Scopus subject areas

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