@article{2d9bb97072604227ae17462df513731b,
title = "Nationwide registry of glecaprevir plus pibrentasvir in the treatment of HCV in Taiwan",
abstract = "The study evaluated the real-world treatment outcomes of Glecaprevir/pibrentasvir (GLE/PIB) including effectiveness, safety and healthcare resource utilization based on a nation-wide registry in Taiwan. The Taiwan HCV Registry (TACR) is a nation-wide platform organized and supervised by the Taiwan Association for the Study of the Liver. Data were analyzed for patients treated with GLE/PIB, including 3144 patients who had treatment outcome available. The primary endpoint was sustained virological response (SVR12, undetectable HCV RNA throughout 12 weeks of end-of-treatment). The overall SVR12 rate was 98.9% (3110/3144), with 98.8%, 99.4% and 100% in patients receiving 8 weeks, 12 weeks, and 16 weeks of GLE/PIB respectively. The SVR12 rate in the treatment-na{\"i}ve cirrhotic patients receiving 8 weeks of GLE/PIB was 98.2% (108/110). The most common AEs were fatigue (7.5%), pruritus (6.7%) and dizziness (1.5%). The mean number of outpatient visits during the GLE/PIB was 5.94 visits for patients treated with 8 weeks, significantly different from the patients treated with 12 weeks of GLE/PIB (6.90 visits). The results support the effectiveness and safety of GLE/PIB treatment in real-world clinical practice, and provide further evidence that the shorter, 8-week GLE/PIB regimen is effective and cost-saving.",
author = "Huang, {Chung Feng} and Kuo, {Hsing Tao} and Chang, {Te Sheng} and Lo, {Ching Chu} and Hung, {Chao Hung} and Huang, {Chien Wei} and Chong, {Lee Won} and Cheng, {Pin Nan} and Yeh, {Ming Lun} and Peng, {Cheng Yuan} and Cheng, {Chien Yu} and Huang, {Jee Fu} and Bair, {Ming Jong} and Lin, {Chih Lang} and Yang, {Chi Chieh} and Wang, {Szu Jen} and Hsieh, {Tsai Yuan} and Lee, {Tzong Hsi} and Lee, {Pei Lun} and Wu, {Wen Chih} and Lin, {Chih Lin} and Su, {Wei Wen} and Yang, {Sheng Shun} and Wang, {Chia Chi} and Hu, {Jui Ting} and Mo, {Lein Ray} and Chen, {Chun Ting} and Huang, {Yi Hsiang} and Chang, {Chun Chao} and Huang, {Chia Sheng} and Chen, {Guei Ying} and Kao, {Chien Neng} and Tai, {Chi Ming} and Liu, {Chun Jen} and Lee, {Mei Hsuan} and Tsai, {Pei Chien} and Dai, {Chia Yen} and Kao, {Jia Horng} and Lin, {Han Chieh} and Chuang, {Wang Long} and Chen, {Chi Yi} and Tseng, {Kuo Chih} and Yu, {Ming Lung}",
note = "Funding Information: The authors would like to thank the Taiwan Association for the Study of the Liver (TASL), the TASL Foundation and Taiwan Liver Research Foundation for grant support and the TACR study group for data collection. We also thank the Center for Medical informatics and Statistics of Kaohsiung Medical University for providing administrative and funding support. Funding Information: The study was supported by grants from Kaohsiung Medical University (100CM-KMU-09, KMU-KI110002, MOST 108–2314-B-037 -066 -MY3, KMU-TC109B05 [Center for Liquid Biopsy and Cohort Research], KMU-TC109A04 [Center for Cancer Research]) and Kaohsiung Medical University Hospital (KMUH109-9R06, KMUH-DK(C)110011, KMUH-DK(C)110004, KMUH109-9R05). Publisher Copyright: {\textcopyright} 2021, The Author(s).",
year = "2021",
month = dec,
doi = "10.1038/s41598-021-03006-3",
language = "English",
volume = "11",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}