National survey of invasive pneumococcal diseases in Taiwan under partial PCV7 vaccination in 2007: Emergence of serotype 19A with high invasive potential

Yu Chia Hsieh; Pen Yi Lin; Cheng Hsun Chiu; Yhu Chering Huang; Kuang Yi Chang; Chun Hsing Liao; Nan Chang Chiu; Yin Ching Chuang; Po Yen Chen; Shan Chwen Chang; Jien Wei Liu; Muh Yong Yen; Jen Hsien Wang; Cheng Yi Liu; Tzou Yien Lin

doi:10.1016/j.vaccine.2009.06.091

National survey of invasive pneumococcal diseases in Taiwan under partial PCV7 vaccination in 2007: Emergence of serotype 19A with high invasive potential

Yu Chia Hsieh, Pen Yi Lin, Cheng Hsun Chiu, Yhu Chering Huang, Kuang Yi Chang, Chun Hsing Liao, Nan Chang Chiu, Yin Ching Chuang, Po Yen Chen, Shan Chwen Chang, Jien Wei Liu, Muh Yong Yen, Jen Hsien Wang, Cheng Yi Liu, Tzou Yien Lin

Research output: Contribution to journal › Article › peer-review

96 Citations (Scopus)

Abstract

We conducted an active, population-based laboratory surveillance study to evaluate the epidemiologic features of invasive pneumococcal disease (IPD) in Taiwan. Concurrently, nasopharyngeal colonization of Streptococcus pneumoniae was evaluated among 1128 healthy children aged ≤5 years. The overall incidence was highest among children aged 2-4 years (15.6/100,000). Serotype 19A, which had never been reported in Taiwan previously, caused a substantial fraction of the invasive diseases (OR, 9.6; 95% CI, 3.1-29.4) among children aged 2-4 years. Comparing serotype distributions of the isolates from nasopharyngeal colonization among children aged ≤5 years, serotypes 14 (OR, 17.3; 95% CI, 5.2-57.9) and 19A (OR, 14.9; 95% CI, 1.9-117) had the highest invasive potential. The study found that serotype 19A expanded in Taiwan, a country with a low 7-valent conjugate pneumococcal vaccine coverage. The 7-valent conjugate pneumococcal vaccines covered 73% of cases in children aged between 2 and 4 years, and 64.7% of cases in children aged <2 years. Among patients aged ≥65 years, the 23-valent pneumococcal polysaccharide vaccine covered 70.4% of cases. In the future, a broader pneumococcal vaccine is needed.

Original language	English
Pages (from-to)	5513-5518
Number of pages	6
Journal	Vaccine
Volume	27
Issue number	40
DOIs	https://doi.org/10.1016/j.vaccine.2009.06.091
Publication status	Published - Sept 4 2009
Externally published	Yes

Keywords

Invasive pneumococcal diseases
Invasive potential
Serotype 19A

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.vaccine.2009.06.091

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Hsieh, Y. C., Lin, P. Y., Chiu, C. H., Huang, Y. C., Chang, K. Y., Liao, C. H., Chiu, N. C., Chuang, Y. C., Chen, P. Y., Chang, S. C., Liu, J. W., Yen, M. Y., Wang, J. H., Liu, C. Y., & Lin, T. Y. (2009). National survey of invasive pneumococcal diseases in Taiwan under partial PCV7 vaccination in 2007: Emergence of serotype 19A with high invasive potential. Vaccine, 27(40), 5513-5518. https://doi.org/10.1016/j.vaccine.2009.06.091

Hsieh, YC, Lin, PY, Chiu, CH, Huang, YC, Chang, KY, Liao, CH, Chiu, NC, Chuang, YC, Chen, PY, Chang, SC, Liu, JW, Yen, MY, Wang, JH, Liu, CY & Lin, TY 2009, 'National survey of invasive pneumococcal diseases in Taiwan under partial PCV7 vaccination in 2007: Emergence of serotype 19A with high invasive potential', Vaccine, vol. 27, no. 40, pp. 5513-5518. https://doi.org/10.1016/j.vaccine.2009.06.091

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title = "National survey of invasive pneumococcal diseases in Taiwan under partial PCV7 vaccination in 2007: Emergence of serotype 19A with high invasive potential",

abstract = "We conducted an active, population-based laboratory surveillance study to evaluate the epidemiologic features of invasive pneumococcal disease (IPD) in Taiwan. Concurrently, nasopharyngeal colonization of Streptococcus pneumoniae was evaluated among 1128 healthy children aged ≤5 years. The overall incidence was highest among children aged 2-4 years (15.6/100,000). Serotype 19A, which had never been reported in Taiwan previously, caused a substantial fraction of the invasive diseases (OR, 9.6; 95% CI, 3.1-29.4) among children aged 2-4 years. Comparing serotype distributions of the isolates from nasopharyngeal colonization among children aged ≤5 years, serotypes 14 (OR, 17.3; 95% CI, 5.2-57.9) and 19A (OR, 14.9; 95% CI, 1.9-117) had the highest invasive potential. The study found that serotype 19A expanded in Taiwan, a country with a low 7-valent conjugate pneumococcal vaccine coverage. The 7-valent conjugate pneumococcal vaccines covered 73% of cases in children aged between 2 and 4 years, and 64.7% of cases in children aged <2 years. Among patients aged ≥65 years, the 23-valent pneumococcal polysaccharide vaccine covered 70.4% of cases. In the future, a broader pneumococcal vaccine is needed.",

keywords = "Invasive pneumococcal diseases, Invasive potential, Serotype 19A",

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doi = "10.1016/j.vaccine.2009.06.091",

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T2 - Emergence of serotype 19A with high invasive potential

AU - Hsieh, Yu Chia

AU - Lin, Pen Yi

AU - Chiu, Cheng Hsun

AU - Huang, Yhu Chering

AU - Chang, Kuang Yi

AU - Liao, Chun Hsing

AU - Chiu, Nan Chang

AU - Chuang, Yin Ching

AU - Chen, Po Yen

AU - Chang, Shan Chwen

AU - Liu, Jien Wei

AU - Yen, Muh Yong

AU - Wang, Jen Hsien

AU - Liu, Cheng Yi

AU - Lin, Tzou Yien

PY - 2009/9/4

Y1 - 2009/9/4

N2 - We conducted an active, population-based laboratory surveillance study to evaluate the epidemiologic features of invasive pneumococcal disease (IPD) in Taiwan. Concurrently, nasopharyngeal colonization of Streptococcus pneumoniae was evaluated among 1128 healthy children aged ≤5 years. The overall incidence was highest among children aged 2-4 years (15.6/100,000). Serotype 19A, which had never been reported in Taiwan previously, caused a substantial fraction of the invasive diseases (OR, 9.6; 95% CI, 3.1-29.4) among children aged 2-4 years. Comparing serotype distributions of the isolates from nasopharyngeal colonization among children aged ≤5 years, serotypes 14 (OR, 17.3; 95% CI, 5.2-57.9) and 19A (OR, 14.9; 95% CI, 1.9-117) had the highest invasive potential. The study found that serotype 19A expanded in Taiwan, a country with a low 7-valent conjugate pneumococcal vaccine coverage. The 7-valent conjugate pneumococcal vaccines covered 73% of cases in children aged between 2 and 4 years, and 64.7% of cases in children aged <2 years. Among patients aged ≥65 years, the 23-valent pneumococcal polysaccharide vaccine covered 70.4% of cases. In the future, a broader pneumococcal vaccine is needed.

AB - We conducted an active, population-based laboratory surveillance study to evaluate the epidemiologic features of invasive pneumococcal disease (IPD) in Taiwan. Concurrently, nasopharyngeal colonization of Streptococcus pneumoniae was evaluated among 1128 healthy children aged ≤5 years. The overall incidence was highest among children aged 2-4 years (15.6/100,000). Serotype 19A, which had never been reported in Taiwan previously, caused a substantial fraction of the invasive diseases (OR, 9.6; 95% CI, 3.1-29.4) among children aged 2-4 years. Comparing serotype distributions of the isolates from nasopharyngeal colonization among children aged ≤5 years, serotypes 14 (OR, 17.3; 95% CI, 5.2-57.9) and 19A (OR, 14.9; 95% CI, 1.9-117) had the highest invasive potential. The study found that serotype 19A expanded in Taiwan, a country with a low 7-valent conjugate pneumococcal vaccine coverage. The 7-valent conjugate pneumococcal vaccines covered 73% of cases in children aged between 2 and 4 years, and 64.7% of cases in children aged <2 years. Among patients aged ≥65 years, the 23-valent pneumococcal polysaccharide vaccine covered 70.4% of cases. In the future, a broader pneumococcal vaccine is needed.

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KW - Invasive potential

KW - Serotype 19A

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ER -

National survey of invasive pneumococcal diseases in Taiwan under partial PCV7 vaccination in 2007: Emergence of serotype 19A with high invasive potential

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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