Nasal dissemination of a single-clone IgH-rearranged conjunctival MALT lymphoma through the nasolacrimal duct: A case report

Chung Yu Hsieh, Yi Ping Liao, Chia Che Wu, Sheng Po Yuan, Jennifer Hui Chun Ho, Rachel Roan, Phui Ly Liew, Ming-Tang Lai, Feipeng Lee

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4 Citations (Scopus)


The aim of the present study was to report a rare case of single-clone, immunoglobulin heavy chain (IgH)-rearranged mucosa-associated lymphoid tissue (MALT) lymphoma in the conjunctiva, with nasal cavity dissemination through the nasolacrimal duct. A 24-year-old female was diagnosed with MALT lymphoma of the nasal cavity at the Department of Otolaryngology, Wan Fang Medical Center, Taipei Medical University (Tapei, Taiwan) in October 2008. A biopsy of the relapsing conjunctival lesion revealed a MALT lymphoma by pathological staining, while a single-clone, IgH-rearranged tumor lesion in the nasal cavity and conjunctiva was confirmed using continuous sinus computed tomography scans and polymerase chain reaction. Tumor lesions were negative for Helicobacter pylori and Chlamydia infection, but exhibited bilateral neck lymph node dissemination. A combination of radiation therapy (a total dosage of 46.8 Gray, in two phases covering the left lacrimal sac, nasal cavity and bilateral neck region) and topical ciprofloxacin plus steroid (0.3% ciprofloxacin 4 times a day and betamethasone eye ointment before sleep for 1 month) was provided as an effective therapeutic strategy, and no recurrence was found in the next 3 years. The nasolacrimal duct serves as a channel for conjunctival tumor spreading and is easily neglected. IgH-involved translocation in MALT lymphoma is a factor in the progression of the disease, and aggressive combination therapy is essential for a high-risk, disseminated IgH-rearranged MALT lymphoma.

Original languageEnglish
Pages (from-to)1007-1010
Number of pages4
JournalOncology Letters
Issue number2
Publication statusPublished - Aug 1 2016


  • Conjunctiva
  • Immunoglobulin heavy chain translocation
  • Mucosa-associated lymphoid tissue lymphoma
  • Nasal cavity
  • Nasolacrimal duct

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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