Myocardial tissue characterization based on a polarization-sensitive optical coherence tomography system with an ultrashort pulsed laser

Chia Wei Sun; Yih Ming Wang; Long Sheng Lu; Chih Wei Lu; I. Jen Hsu; Meng Tsan Tsai; C. C. Yang; Yean Woei Kiang; Chau Chung Wu

doi:10.1117/1.2363358

Myocardial tissue characterization based on a polarization-sensitive optical coherence tomography system with an ultrashort pulsed laser

Chia Wei Sun, Yih Ming Wang, Long Sheng Lu, Chih Wei Lu, I. Jen Hsu, Meng Tsan Tsai, C. C. Yang, Yean Woei Kiang, Chau Chung Wu

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

A polarization-sensitive optical coherence tomography (PSOCT) system using a femtosecond-laser as the broadband light source is implemented with the axial resolution of 5 μm in free space. Through the design of path-length difference between the two polarization inputs and the modulation of one of the polarization inputs, the PSOCT images of various input and output polarization combinations can be distinguished and simultaneously collected. The PSOCT system is then used for in vitro scanning of the myocardium tissues of normal and infarcted rat hearts. The destruction of the birefringence nature of the fiber muscle in the infarcted heart can be clearly observed.

Original language	English
Article number	054016
Journal	Journal of Biomedical Optics
Volume	11
Issue number	5
DOIs	https://doi.org/10.1117/1.2363358
Publication status	Published - Sept 2006
Externally published	Yes

Keywords

Lasers
Medical imaging
Microscopy
Optical systems
Polarization

ASJC Scopus subject areas

Biomedical Engineering
Biomaterials
Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging
Radiological and Ultrasound Technology
Clinical Biochemistry

Access to Document

10.1117/1.2363358

Cite this

@article{857a792a425e4ea5944c84c811f8885b,

title = "Myocardial tissue characterization based on a polarization-sensitive optical coherence tomography system with an ultrashort pulsed laser",

abstract = "A polarization-sensitive optical coherence tomography (PSOCT) system using a femtosecond-laser as the broadband light source is implemented with the axial resolution of 5 μm in free space. Through the design of path-length difference between the two polarization inputs and the modulation of one of the polarization inputs, the PSOCT images of various input and output polarization combinations can be distinguished and simultaneously collected. The PSOCT system is then used for in vitro scanning of the myocardium tissues of normal and infarcted rat hearts. The destruction of the birefringence nature of the fiber muscle in the infarcted heart can be clearly observed.",

keywords = "Lasers, Medical imaging, Microscopy, Optical systems, Polarization",

author = "Sun, {Chia Wei} and Wang, {Yih Ming} and Lu, {Long Sheng} and Lu, {Chih Wei} and Hsu, {I. Jen} and Tsai, {Meng Tsan} and Yang, {C. C.} and Kiang, {Yean Woei} and Wu, {Chau Chung}",

year = "2006",

month = sep,

doi = "10.1117/1.2363358",

language = "English",

volume = "11",

journal = "Journal of Biomedical Optics",

issn = "1083-3668",

publisher = "SPIE",

number = "5",

}

TY - JOUR

T1 - Myocardial tissue characterization based on a polarization-sensitive optical coherence tomography system with an ultrashort pulsed laser

AU - Sun, Chia Wei

AU - Wang, Yih Ming

AU - Lu, Long Sheng

AU - Lu, Chih Wei

AU - Hsu, I. Jen

AU - Tsai, Meng Tsan

AU - Yang, C. C.

AU - Kiang, Yean Woei

AU - Wu, Chau Chung

PY - 2006/9

Y1 - 2006/9

N2 - A polarization-sensitive optical coherence tomography (PSOCT) system using a femtosecond-laser as the broadband light source is implemented with the axial resolution of 5 μm in free space. Through the design of path-length difference between the two polarization inputs and the modulation of one of the polarization inputs, the PSOCT images of various input and output polarization combinations can be distinguished and simultaneously collected. The PSOCT system is then used for in vitro scanning of the myocardium tissues of normal and infarcted rat hearts. The destruction of the birefringence nature of the fiber muscle in the infarcted heart can be clearly observed.

AB - A polarization-sensitive optical coherence tomography (PSOCT) system using a femtosecond-laser as the broadband light source is implemented with the axial resolution of 5 μm in free space. Through the design of path-length difference between the two polarization inputs and the modulation of one of the polarization inputs, the PSOCT images of various input and output polarization combinations can be distinguished and simultaneously collected. The PSOCT system is then used for in vitro scanning of the myocardium tissues of normal and infarcted rat hearts. The destruction of the birefringence nature of the fiber muscle in the infarcted heart can be clearly observed.

KW - Lasers

KW - Medical imaging

KW - Microscopy

KW - Optical systems

KW - Polarization

UR - http://www.scopus.com/inward/record.url?scp=33845372003&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845372003&partnerID=8YFLogxK

U2 - 10.1117/1.2363358

DO - 10.1117/1.2363358

M3 - Article

C2 - 17092165

AN - SCOPUS:33845372003

SN - 1083-3668

VL - 11

JO - Journal of Biomedical Optics

JF - Journal of Biomedical Optics

IS - 5

M1 - 054016

ER -

Myocardial tissue characterization based on a polarization-sensitive optical coherence tomography system with an ultrashort pulsed laser

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this