Mutant Lines of Guinea Pig L2C Leukemia. II. Comparative Cytogenetic Studies and Banding Analyses of Normal and Leukemic Karyotypes

J. Whang Peng; E. C. Lee

doi:10.1093/jnci/57.4.897

Mutant Lines of Guinea Pig L₂C Leukemia. II. Comparative Cytogenetic Studies and Banding Analyses of Normal and Leukemic Karyotypes

J. Whang Peng, E. C. Lee

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Chromosomes of normal guinea pig (strain 2) cells and of cell lines derived from a spontaneously arising leukemia were analyzed in detail. All cell lines studied, LG-L₂C, GH-L₂C, BZ-L_*C, and EN-L₂C, contained one M1 marker and two X chromosomes, in addition to other chromosome abnormalities specific for each cell line. The presence of the M1 marker and the two X chromosomes confirmed that all of these leukemic cell lines are derived from one ancestral line. Comparison of the chromosome markers and immunologic characteristics of these lines revealed that possibly the gene involved in the determination of C₃receptor sites is located on the terminal portion of the long arm of chromosome #2, but no other correlations could be made.

Original language	English
Pages (from-to)	897-905
Number of pages	9
Journal	Journal of the National Cancer Institute
Volume	57
Issue number	4
DOIs	https://doi.org/10.1093/jnci/57.4.897
Publication status	Published - Jan 1 1976
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/jnci/57.4.897

Cite this

@article{bf1bb6915c554db18ca0b7edcb35ff00,

title = "Mutant Lines of Guinea Pig L2C Leukemia. II. Comparative Cytogenetic Studies and Banding Analyses of Normal and Leukemic Karyotypes",

abstract = "Chromosomes of normal guinea pig (strain 2) cells and of cell lines derived from a spontaneously arising leukemia were analyzed in detail. All cell lines studied, LG-L2C, GH-L2C, BZ-L*C, and EN-L2C, contained one M1 marker and two X chromosomes, in addition to other chromosome abnormalities specific for each cell line. The presence of the M1 marker and the two X chromosomes confirmed that all of these leukemic cell lines are derived from one ancestral line. Comparison of the chromosome markers and immunologic characteristics of these lines revealed that possibly the gene involved in the determination of C3receptor sites is located on the terminal portion of the long arm of chromosome #2, but no other correlations could be made.",

author = "Peng, {J. Whang} and Lee, {E. C.}",

note = "Funding Information: I Received December 19, 1975; accepted March 23, 1976. 2 Cytogenetic Oncology Section, Medicine Branch, National Cancer Institute (NCI), National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Md. 20014. 3 Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health. 4 We thank Dr. E. M. Nadel for his assistance with the L2C genealogy and in obtaining the various L2C cell lines.",

year = "1976",

month = jan,

day = "1",

doi = "10.1093/jnci/57.4.897",

language = "English",

volume = "57",

pages = "897--905",

journal = "Journal of the National Cancer Institute",

issn = "0027-8874",

publisher = "Oxford University Press",

number = "4",

}

TY - JOUR

T1 - Mutant Lines of Guinea Pig L2C Leukemia. II. Comparative Cytogenetic Studies and Banding Analyses of Normal and Leukemic Karyotypes

AU - Peng, J. Whang

AU - Lee, E. C.

N1 - Funding Information: I Received December 19, 1975; accepted March 23, 1976. 2 Cytogenetic Oncology Section, Medicine Branch, National Cancer Institute (NCI), National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Md. 20014. 3 Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health. 4 We thank Dr. E. M. Nadel for his assistance with the L2C genealogy and in obtaining the various L2C cell lines.

PY - 1976/1/1

Y1 - 1976/1/1

N2 - Chromosomes of normal guinea pig (strain 2) cells and of cell lines derived from a spontaneously arising leukemia were analyzed in detail. All cell lines studied, LG-L2C, GH-L2C, BZ-L*C, and EN-L2C, contained one M1 marker and two X chromosomes, in addition to other chromosome abnormalities specific for each cell line. The presence of the M1 marker and the two X chromosomes confirmed that all of these leukemic cell lines are derived from one ancestral line. Comparison of the chromosome markers and immunologic characteristics of these lines revealed that possibly the gene involved in the determination of C3receptor sites is located on the terminal portion of the long arm of chromosome #2, but no other correlations could be made.

AB - Chromosomes of normal guinea pig (strain 2) cells and of cell lines derived from a spontaneously arising leukemia were analyzed in detail. All cell lines studied, LG-L2C, GH-L2C, BZ-L*C, and EN-L2C, contained one M1 marker and two X chromosomes, in addition to other chromosome abnormalities specific for each cell line. The presence of the M1 marker and the two X chromosomes confirmed that all of these leukemic cell lines are derived from one ancestral line. Comparison of the chromosome markers and immunologic characteristics of these lines revealed that possibly the gene involved in the determination of C3receptor sites is located on the terminal portion of the long arm of chromosome #2, but no other correlations could be made.

UR - http://www.scopus.com/inward/record.url?scp=0017171297&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017171297&partnerID=8YFLogxK

U2 - 10.1093/jnci/57.4.897

DO - 10.1093/jnci/57.4.897

M3 - Article

C2 - 1034020

AN - SCOPUS:0017171297

SN - 0027-8874

VL - 57

SP - 897

EP - 905

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

IS - 4

ER -