Multiple roles for basement membrane proteins in cancer progression and EMT

Samarpita Banerjee; Wen-Cheng Lo; Payel Majumder; Debleena Roy; Mimosa Ghorai; Nusrat K Shaikh; Nishi Kant; Mahipal S Shekhawat; Vijaykumar Shivaji Gadekar; Suchanda Ghosh; Ercan Bursal; Faris Alrumaihi; Navneet Kumar Dubey; Sanjay Kumar; Danish Iqbal; Wael Alturaiki; Vijay Jagdish Upadhye; Niraj Kumar Jha; Abhijit Dey; Rohit Gundamaraju

doi:10.1016/j.ejcb.2022.151220

Multiple roles for basement membrane proteins in cancer progression and EMT

Samarpita Banerjee, Wen-Cheng Lo, Payel Majumder, Debleena Roy, Mimosa Ghorai, Nusrat K Shaikh, Nishi Kant, Mahipal S Shekhawat, Vijaykumar Shivaji Gadekar, Suchanda Ghosh, Ercan Bursal, Faris Alrumaihi, Navneet Kumar Dubey, Sanjay Kumar, Danish Iqbal, Wael Alturaiki, Vijay Jagdish Upadhye, Niraj Kumar Jha, Abhijit Dey, Rohit Gundamaraju

Research output: Contribution to journal › Review article › peer-review

Abstract

Metastasis or the progression of malignancy poses a major challenge in cancer therapy and is the principal reason for increased mortality. The epithelial-mesenchymal transition (EMT) of the basement membrane (BM) allows cells of epithelial phenotype to transform into a mesenchymal-like (quasi-mesenchymal) phenotype and metastasize via the lymphovascular system through a metastatic cascade by intravasation and extravasation. This helps in the progression of carcinoma from the primary site to distant organs. Collagen, laminin, and integrin are the prime components of BM and help in tumor cell metastasis, which makes them ideal cancer drug targets. Further, recent studies have shown that collagen, laminin, and integrin can be used as a biomarker for metastatic cells. In this review, we have summarized the current knowledge of such therapeutics, which are either currently in preclinical or clinical stages and could be promising cancer therapeutics. DATA AVAILABILITY: Not applicable.

Original language	English
Pages (from-to)	151220
Journal	European Journal of Cell Biology
Volume	101
Issue number	2
DOIs	https://doi.org/10.1016/j.ejcb.2022.151220
Publication status	Published - Apr 2022

Keywords

Basement Membrane/metabolism
Collagen
Epithelial-Mesenchymal Transition
Humans
Integrins
Laminin
Membrane Proteins
Neoplasms/therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejcb.2022.151220

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Banerjee, S., Lo, W-C., Majumder, P., Roy, D., Ghorai, M., Shaikh, N. K., Kant, N., Shekhawat, M. S., Gadekar, V. S., Ghosh, S., Bursal, E., Alrumaihi, F., Dubey, N. K., Kumar, S., Iqbal, D., Alturaiki, W., Upadhye, V. J., Jha, N. K., Dey, A., & Gundamaraju, R. (2022). Multiple roles for basement membrane proteins in cancer progression and EMT. European Journal of Cell Biology, 101(2), 151220. https://doi.org/10.1016/j.ejcb.2022.151220

Banerjee, S, Lo, W-C, Majumder, P, Roy, D, Ghorai, M, Shaikh, NK, Kant, N, Shekhawat, MS, Gadekar, VS, Ghosh, S, Bursal, E, Alrumaihi, F, Dubey, NK, Kumar, S, Iqbal, D, Alturaiki, W, Upadhye, VJ, Jha, NK, Dey, A & Gundamaraju, R 2022, 'Multiple roles for basement membrane proteins in cancer progression and EMT', European Journal of Cell Biology, vol. 101, no. 2, pp. 151220. https://doi.org/10.1016/j.ejcb.2022.151220

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title = "Multiple roles for basement membrane proteins in cancer progression and EMT",

abstract = "Metastasis or the progression of malignancy poses a major challenge in cancer therapy and is the principal reason for increased mortality. The epithelial-mesenchymal transition (EMT) of the basement membrane (BM) allows cells of epithelial phenotype to transform into a mesenchymal-like (quasi-mesenchymal) phenotype and metastasize via the lymphovascular system through a metastatic cascade by intravasation and extravasation. This helps in the progression of carcinoma from the primary site to distant organs. Collagen, laminin, and integrin are the prime components of BM and help in tumor cell metastasis, which makes them ideal cancer drug targets. Further, recent studies have shown that collagen, laminin, and integrin can be used as a biomarker for metastatic cells. In this review, we have summarized the current knowledge of such therapeutics, which are either currently in preclinical or clinical stages and could be promising cancer therapeutics. DATA AVAILABILITY: Not applicable.",

keywords = "Basement Membrane/metabolism, Collagen, Epithelial-Mesenchymal Transition, Humans, Integrins, Laminin, Membrane Proteins, Neoplasms/therapy",

author = "Samarpita Banerjee and Wen-Cheng Lo and Payel Majumder and Debleena Roy and Mimosa Ghorai and Shaikh, {Nusrat K} and Nishi Kant and Shekhawat, {Mahipal S} and Gadekar, {Vijaykumar Shivaji} and Suchanda Ghosh and Ercan Bursal and Faris Alrumaihi and Dubey, {Navneet Kumar} and Sanjay Kumar and Danish Iqbal and Wael Alturaiki and Upadhye, {Vijay Jagdish} and Jha, {Niraj Kumar} and Abhijit Dey and Rohit Gundamaraju",

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doi = "10.1016/j.ejcb.2022.151220",

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volume = "101",

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T1 - Multiple roles for basement membrane proteins in cancer progression and EMT

AU - Banerjee, Samarpita

AU - Lo, Wen-Cheng

AU - Majumder, Payel

AU - Roy, Debleena

AU - Ghorai, Mimosa

AU - Shaikh, Nusrat K

AU - Kant, Nishi

AU - Shekhawat, Mahipal S

AU - Gadekar, Vijaykumar Shivaji

AU - Ghosh, Suchanda

AU - Bursal, Ercan

AU - Alrumaihi, Faris

AU - Dubey, Navneet Kumar

AU - Kumar, Sanjay

AU - Iqbal, Danish

AU - Alturaiki, Wael

AU - Upadhye, Vijay Jagdish

AU - Jha, Niraj Kumar

AU - Dey, Abhijit

AU - Gundamaraju, Rohit

PY - 2022/4

Y1 - 2022/4

N2 - Metastasis or the progression of malignancy poses a major challenge in cancer therapy and is the principal reason for increased mortality. The epithelial-mesenchymal transition (EMT) of the basement membrane (BM) allows cells of epithelial phenotype to transform into a mesenchymal-like (quasi-mesenchymal) phenotype and metastasize via the lymphovascular system through a metastatic cascade by intravasation and extravasation. This helps in the progression of carcinoma from the primary site to distant organs. Collagen, laminin, and integrin are the prime components of BM and help in tumor cell metastasis, which makes them ideal cancer drug targets. Further, recent studies have shown that collagen, laminin, and integrin can be used as a biomarker for metastatic cells. In this review, we have summarized the current knowledge of such therapeutics, which are either currently in preclinical or clinical stages and could be promising cancer therapeutics. DATA AVAILABILITY: Not applicable.

AB - Metastasis or the progression of malignancy poses a major challenge in cancer therapy and is the principal reason for increased mortality. The epithelial-mesenchymal transition (EMT) of the basement membrane (BM) allows cells of epithelial phenotype to transform into a mesenchymal-like (quasi-mesenchymal) phenotype and metastasize via the lymphovascular system through a metastatic cascade by intravasation and extravasation. This helps in the progression of carcinoma from the primary site to distant organs. Collagen, laminin, and integrin are the prime components of BM and help in tumor cell metastasis, which makes them ideal cancer drug targets. Further, recent studies have shown that collagen, laminin, and integrin can be used as a biomarker for metastatic cells. In this review, we have summarized the current knowledge of such therapeutics, which are either currently in preclinical or clinical stages and could be promising cancer therapeutics. DATA AVAILABILITY: Not applicable.

KW - Basement Membrane/metabolism

KW - Collagen

KW - Epithelial-Mesenchymal Transition

KW - Humans

KW - Integrins

KW - Laminin

KW - Membrane Proteins

KW - Neoplasms/therapy

U2 - 10.1016/j.ejcb.2022.151220

DO - 10.1016/j.ejcb.2022.151220

M3 - Review article

C2 - 35366585

SN - 0171-9335

VL - 101

SP - 151220

JO - European Journal of Cell Biology

JF - European Journal of Cell Biology

IS - 2

ER -

Multiple roles for basement membrane proteins in cancer progression and EMT

Abstract

Keywords

UN SDGs

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