Multiple detection modalities and disease natural history of breast cancer.

Tony Hsiu Hsi Chen, Amy Ming Fang Yen, Grace Hui Min Wu, Li Sheng Chen, Yueh Hsia Chiu

Research output: Contribution to journalReview articlepeer-review


Multiple detection modalities have increasingly gained attention in population-based screening. However, the disease natural history and its efficacy have been barely addressed. We reviewed a series of articles addressing multiple detection modalities including mammography, ultrasound and magnetic resonance image between 1995 and 2005. A stochastic model was developed to estimate transition parameters pertaining to the disease natural history defined by multiple detection modalities. The effectiveness of the combination of ultrasound or magnetic resonance image (MRI) with mammography was projected using a series of computer simulation models.The results indicated that multiple detection modalities may lead to reduced mortality. However, the benefit and the selection of detection modalities are affected by biological factors including age, breast tissue type and histological type. In addition, other social factors may also affect the utilization of multiple detection modalities.

Original languageEnglish
Pages (from-to)78-81
Number of pages4
JournalMedinfo. MEDINFO
Issue numberPt 1
Publication statusPublished - 2007
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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