Multifactorial causes of irritating bladder symptoms in patients with sjögren's syndrome

Kuang Lun Lee, Chung Shiu Dong, Mao Yuan Chen, Chen Hsun Ho, Huai Ching Tai, Shun Fa Hung, Hong Jeng Yu

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Aims Patients with Sjögren's syndrome (SS) are reported to have an increased severity of irritating bladder symptoms, including urinary frequency and urgency. The mechanism remains unclear. The aim of this study is to elucidate the possible etiologies underlying this problem. Methods Data from 23 female patients with SS (15 primary and 8 secondary) who were treated in the urology clinic for chronic, irritating bladder symptoms were studied. Evaluation of each subject is composed of lower urinary tract symptoms (LUTS), bladder diary entries, and urodynamic studies, which also included an ice water test (IWT) to detect the presence of a C-fiber mediated micturition pathway. Interstitial cystitis (IC) was diagnosed with post-hydrodilatation cystoscopic findings of glomerulations and a KCl test. Results These patients complained predominantly of overactive bladder symptoms (OAB), including frequency (n = 20, 87%), nocturia (n = 16, 66%), and urgency (n = 12, 52%). Based on the aforementioned evaluations, four patients (17%) had polyuria with normal bladder function, nine patients (39%) had detrusor overactivity (DO), seven patients (32%) had bladder hypersensitivity (including two patients (9%) diagnosed with IC), and three patients (13%) had negative findings. Ice water instillation neither elicited novel involuntary contractions, both in those with or without DO. Five of the six patients (83%) with DO versus one of the four patients (25%) without DO responded to antimuscarinic therapy. Conclusions Various factors contribute to the irritating bladder symptoms in patients with SS, with DO being predominant. The LUTS developed in patients with SS are not due to any specific single etiology and that each patient must be individually carefully evaluated. Neurourol. Urodynam. 30:97-101, 2011.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalNeurourology and Urodynamics
Issue number1
Publication statusPublished - Jan 1 2011
Externally publishedYes


  • overactive bladder symptoms
  • Sjogren's syndrome
  • urodynamic studies

ASJC Scopus subject areas

  • Clinical Neurology
  • Urology


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