TY - JOUR
T1 - Multifaceted regenerative lives of expired platelets in the second decade of the 21st century
AU - Burnouf, Thierry
AU - Goubran, Hadi Alphonse
AU - Seghatchian, Jerard
N1 - Publisher Copyright:
© 2014 Elsevier Ltd.
PY - 2014
Y1 - 2014
N2 - A traditional concept in transfusion medicine is the expiration of platelet concentrates 5-7 days after collection due to storage conditions that favor the risks of bacterial contamination and may lead to a gradual alteration of platelet hemostatic power. Newer findings are strongly suggesting that, after their supposed expiration date, platelet concentrates still contain multiple functional growth factors and cytokines and actually have unaltered power for application in regenerative medicine and cell therapy. Expired platelets can be a valuable source of growth factors to promote the healing of wounds, and can be used for ex vivo expansion of stem cells. There is also preliminary evidence that infusible platelet membrane (IPM) from outdated platelet concentrates and thrombosomes have potential clinical applications as hemostatic products. Experimental work is certainly needed to further validate and standardize the clinical potential of "expired" platelet blood products in human clinical medicine. However, strong evidence accumulates toward a potential for further manufacturing avenues of expired platelet concentrates into valuable therapeutic and clinically relevant products.
AB - A traditional concept in transfusion medicine is the expiration of platelet concentrates 5-7 days after collection due to storage conditions that favor the risks of bacterial contamination and may lead to a gradual alteration of platelet hemostatic power. Newer findings are strongly suggesting that, after their supposed expiration date, platelet concentrates still contain multiple functional growth factors and cytokines and actually have unaltered power for application in regenerative medicine and cell therapy. Expired platelets can be a valuable source of growth factors to promote the healing of wounds, and can be used for ex vivo expansion of stem cells. There is also preliminary evidence that infusible platelet membrane (IPM) from outdated platelet concentrates and thrombosomes have potential clinical applications as hemostatic products. Experimental work is certainly needed to further validate and standardize the clinical potential of "expired" platelet blood products in human clinical medicine. However, strong evidence accumulates toward a potential for further manufacturing avenues of expired platelet concentrates into valuable therapeutic and clinically relevant products.
KW - Ex vivo cell expansion
KW - Expired platelets
KW - Hemostatic/wound healing products
KW - Infusible platelet membrane
KW - Platelet lysates/microparticles/growth factors
KW - Regenerative medicine/cell therapy
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U2 - 10.1016/j.transci.2014.08.006
DO - 10.1016/j.transci.2014.08.006
M3 - Review article
C2 - 25189105
AN - SCOPUS:84922616163
SN - 1473-0502
VL - 51
SP - 107
EP - 112
JO - Transfusion and Apheresis Science
JF - Transfusion and Apheresis Science
IS - 2
ER -