Multi-scale mapping for collagen-regulated mineralization in bone remodeling of additive manufacturing porous implants

Pei I. Tsai; Tu Ngoc Lam; Meng Huang Wu; Kuan Ying Tseng; Yuan Wei Chang; Jui Sheng Sun; Yen Yao Li; Ming Hsueh Lee; San Yuan Chen; Chung Kai Chang; Chun Jen Su; Chia Hsien Lin; Ching Yu Chiang; Ching Shun Ku; Nien Ti Tsou; Shao Ju Shih; Chun Chieh Wang; E. Wen Huang

doi:10.1016/j.matchemphys.2019.03.047

Multi-scale mapping for collagen-regulated mineralization in bone remodeling of additive manufacturing porous implants

Pei I. Tsai, Tu Ngoc Lam, Meng Huang Wu, Kuan Ying Tseng, Yuan Wei Chang, Jui Sheng Sun, Yen Yao Li, Ming Hsueh Lee, San Yuan Chen, Chung Kai Chang, Chun Jen Su, Chia Hsien Lin, Ching Yu Chiang, Ching Shun Ku, Nien Ti Tsou, Shao Ju Shih, Chun Chieh Wang, E. Wen Huang

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Long term success of metallic fusion cages depends on mechanobiological processes through the bone incorporation and rich osseointegration. An optimal configuration of porous titanium-aluminum-vanadium (Ti–6Al–4V) implant fabricated via the additive manufacturing was evaluated in complimentary structure examinations to investigate the growth of autologous osseous at multi-length scales. X-ray microcomputed tomography (micro-CT) and transmission X-ray microscopy (TXM) using newly-built analysis method indicate the porous Ti–6Al–4V is much better for bone ingrowth compared to commercially non-porous titanium (Ti) and porous tantalum (Ta) implants at the ultramicrostructural level. The evolution of bone formation and remodeling acquired by nano X-ray Laue diffraction mapping exhibits the isotropic orientation and low crystallinity of all newly formed bone whereas mature bone in Ti–6Al–4V discloses the preferential alignment and higher crystallinity volumes of constituent hydroxyapatite (HA) crystallites. The high degree in mineral crystallinity of the fully mature bone suggests additive manufactured Ti–6Al–4V pores enhance the collagen-regulated mineralization.

Original language	English
Pages (from-to)	83-92
Number of pages	10
Journal	Materials Chemistry and Physics
Volume	230
DOIs	https://doi.org/10.1016/j.matchemphys.2019.03.047
Publication status	Published - May 15 2019

Keywords

Additive manufacturing
Implant
Nano X-ray Laue diffraction mapping
Small X-ray angle scattering
X-ray tomography

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics

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Tsai, P. I., Lam, T. N., Wu, M. H., Tseng, K. Y., Chang, Y. W., Sun, J. S., Li, Y. Y., Lee, M. H., Chen, S. Y., Chang, C. K., Su, C. J., Lin, C. H., Chiang, C. Y., Ku, C. S., Tsou, N. T., Shih, S. J., Wang, C. C., & Huang, E. W. (2019). Multi-scale mapping for collagen-regulated mineralization in bone remodeling of additive manufacturing porous implants. Materials Chemistry and Physics, 230, 83-92. https://doi.org/10.1016/j.matchemphys.2019.03.047

Tsai, PI, Lam, TN, Wu, MH, Tseng, KY, Chang, YW, Sun, JS, Li, YY, Lee, MH, Chen, SY, Chang, CK, Su, CJ, Lin, CH, Chiang, CY, Ku, CS, Tsou, NT, Shih, SJ, Wang, CC & Huang, EW 2019, 'Multi-scale mapping for collagen-regulated mineralization in bone remodeling of additive manufacturing porous implants', Materials Chemistry and Physics, vol. 230, pp. 83-92. https://doi.org/10.1016/j.matchemphys.2019.03.047

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title = "Multi-scale mapping for collagen-regulated mineralization in bone remodeling of additive manufacturing porous implants",

abstract = "Long term success of metallic fusion cages depends on mechanobiological processes through the bone incorporation and rich osseointegration. An optimal configuration of porous titanium-aluminum-vanadium (Ti–6Al–4V) implant fabricated via the additive manufacturing was evaluated in complimentary structure examinations to investigate the growth of autologous osseous at multi-length scales. X-ray microcomputed tomography (micro-CT) and transmission X-ray microscopy (TXM) using newly-built analysis method indicate the porous Ti–6Al–4V is much better for bone ingrowth compared to commercially non-porous titanium (Ti) and porous tantalum (Ta) implants at the ultramicrostructural level. The evolution of bone formation and remodeling acquired by nano X-ray Laue diffraction mapping exhibits the isotropic orientation and low crystallinity of all newly formed bone whereas mature bone in Ti–6Al–4V discloses the preferential alignment and higher crystallinity volumes of constituent hydroxyapatite (HA) crystallites. The high degree in mineral crystallinity of the fully mature bone suggests additive manufactured Ti–6Al–4V pores enhance the collagen-regulated mineralization.",

keywords = "Additive manufacturing, Implant, Nano X-ray Laue diffraction mapping, Small X-ray angle scattering, X-ray tomography",

author = "Tsai, {Pei I.} and Lam, {Tu Ngoc} and Wu, {Meng Huang} and Tseng, {Kuan Ying} and Chang, {Yuan Wei} and Sun, {Jui Sheng} and Li, {Yen Yao} and Lee, {Ming Hsueh} and Chen, {San Yuan} and Chang, {Chung Kai} and Su, {Chun Jen} and Lin, {Chia Hsien} and Chiang, {Ching Yu} and Ku, {Ching Shun} and Tsou, {Nien Ti} and Shih, {Shao Ju} and Wang, {Chun Chieh} and Huang, {E. Wen}",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = may,

day = "15",

doi = "10.1016/j.matchemphys.2019.03.047",

language = "English",

volume = "230",

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T1 - Multi-scale mapping for collagen-regulated mineralization in bone remodeling of additive manufacturing porous implants

AU - Tsai, Pei I.

AU - Lam, Tu Ngoc

AU - Wu, Meng Huang

AU - Tseng, Kuan Ying

AU - Chang, Yuan Wei

AU - Sun, Jui Sheng

AU - Li, Yen Yao

AU - Lee, Ming Hsueh

AU - Chen, San Yuan

AU - Chang, Chung Kai

AU - Su, Chun Jen

AU - Lin, Chia Hsien

AU - Chiang, Ching Yu

AU - Ku, Ching Shun

AU - Tsou, Nien Ti

AU - Shih, Shao Ju

AU - Wang, Chun Chieh

AU - Huang, E. Wen

PY - 2019/5/15

Y1 - 2019/5/15

N2 - Long term success of metallic fusion cages depends on mechanobiological processes through the bone incorporation and rich osseointegration. An optimal configuration of porous titanium-aluminum-vanadium (Ti–6Al–4V) implant fabricated via the additive manufacturing was evaluated in complimentary structure examinations to investigate the growth of autologous osseous at multi-length scales. X-ray microcomputed tomography (micro-CT) and transmission X-ray microscopy (TXM) using newly-built analysis method indicate the porous Ti–6Al–4V is much better for bone ingrowth compared to commercially non-porous titanium (Ti) and porous tantalum (Ta) implants at the ultramicrostructural level. The evolution of bone formation and remodeling acquired by nano X-ray Laue diffraction mapping exhibits the isotropic orientation and low crystallinity of all newly formed bone whereas mature bone in Ti–6Al–4V discloses the preferential alignment and higher crystallinity volumes of constituent hydroxyapatite (HA) crystallites. The high degree in mineral crystallinity of the fully mature bone suggests additive manufactured Ti–6Al–4V pores enhance the collagen-regulated mineralization.

AB - Long term success of metallic fusion cages depends on mechanobiological processes through the bone incorporation and rich osseointegration. An optimal configuration of porous titanium-aluminum-vanadium (Ti–6Al–4V) implant fabricated via the additive manufacturing was evaluated in complimentary structure examinations to investigate the growth of autologous osseous at multi-length scales. X-ray microcomputed tomography (micro-CT) and transmission X-ray microscopy (TXM) using newly-built analysis method indicate the porous Ti–6Al–4V is much better for bone ingrowth compared to commercially non-porous titanium (Ti) and porous tantalum (Ta) implants at the ultramicrostructural level. The evolution of bone formation and remodeling acquired by nano X-ray Laue diffraction mapping exhibits the isotropic orientation and low crystallinity of all newly formed bone whereas mature bone in Ti–6Al–4V discloses the preferential alignment and higher crystallinity volumes of constituent hydroxyapatite (HA) crystallites. The high degree in mineral crystallinity of the fully mature bone suggests additive manufactured Ti–6Al–4V pores enhance the collagen-regulated mineralization.

KW - Additive manufacturing

KW - Implant

KW - Nano X-ray Laue diffraction mapping

KW - Small X-ray angle scattering

KW - X-ray tomography

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EP - 92

JO - Materials Chemistry and Physics

JF - Materials Chemistry and Physics

ER -

Multi-scale mapping for collagen-regulated mineralization in bone remodeling of additive manufacturing porous implants

Abstract

Keywords

ASJC Scopus subject areas

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