Abstract
Th2 cytokines are associated with the airway inflammation and hyperreactivity in allergic asthma and are potential targets for developing novel therapies. The efficacy of a mucosal cytokine-gene transfer approach was examined in a mouse model for allergic asthma. We showed first that mucosal IFN-γ gene transfer results in a significant expression of IFN-γ in the pulmonary epithelium. Significantly, this approach inhibits both Ag- and Th2-cell-induced pulmonary eosinophilia and airway hyperreactivity. These findings suggest that mucosal IFN-γ gene transfer is effective in modulating pulmonary allergic responses and provides a basis for developing a novel therapeutic approach.
Original language | English |
---|---|
Pages (from-to) | 3216-3219 |
Number of pages | 4 |
Journal | Journal of Immunology |
Volume | 157 |
Issue number | 8 |
Publication status | Published - Oct 15 1996 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology