Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo

An Chi Tsai; Shiow Lin Pan; Cho Hwa Liao; Jih Hwa Guh; Shih Wei Wang; Hui Lung Sun; Yi Nan Liu; Chien Chih Chen; Chien Chang Shen; Ya Ling Chang; Che Ming Teng

doi:10.1016/j.canlet.2009.11.020

Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo

An Chi Tsai, Shiow Lin Pan, Cho Hwa Liao, Jih Hwa Guh, Shih Wei Wang, Hui Lung Sun, Yi Nan Liu, Chien Chih Chen, Chien Chang Shen, Ya Ling Chang, Che Ming Teng

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

Attacking angiogenesis is considered an effective strategy for controls the expansion and metastasis of tumors and other related-diseases. The aim of this study was to assess the effects of moscatilin, a bibenzyl derivative, on VEGF and bFGF-induced angiogenesis in cultured human umbilical vein endothelial cells (HUVECs) in vitro and in vivo. Moscatilin significantly inhibited growth of lung cancer cell line A549 (NSCLC) and suppressed growth factor-induced neovascularization. In addition, VEGF- and bFGF-induced cell proliferation, migration, and tube formation of HUVECs was markedly inhibited by moscatilin. Western blotting analysis of cell signaling molecules indicated that moscatilin inhibited ERK1/2, Akt, and eNOS signaling pathways in HUVECs. These results suggest that inhibition of angiogenesis by moscatilin may be a major mechanism in cancer therapy.

Original language	English
Pages (from-to)	163-170
Number of pages	8
Journal	Cancer Letters
Volume	292
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2009.11.020
Publication status	Published - Jun 2010

Keywords

Angiogenesis
BFGF
Endothelial cells
Moscatilin
VEGF

ASJC Scopus subject areas

Cancer Research
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2009.11.020

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title = "Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo",

abstract = "Attacking angiogenesis is considered an effective strategy for controls the expansion and metastasis of tumors and other related-diseases. The aim of this study was to assess the effects of moscatilin, a bibenzyl derivative, on VEGF and bFGF-induced angiogenesis in cultured human umbilical vein endothelial cells (HUVECs) in vitro and in vivo. Moscatilin significantly inhibited growth of lung cancer cell line A549 (NSCLC) and suppressed growth factor-induced neovascularization. In addition, VEGF- and bFGF-induced cell proliferation, migration, and tube formation of HUVECs was markedly inhibited by moscatilin. Western blotting analysis of cell signaling molecules indicated that moscatilin inhibited ERK1/2, Akt, and eNOS signaling pathways in HUVECs. These results suggest that inhibition of angiogenesis by moscatilin may be a major mechanism in cancer therapy.",

keywords = "Angiogenesis, BFGF, Endothelial cells, Moscatilin, VEGF",

author = "Tsai, {An Chi} and Pan, {Shiow Lin} and Liao, {Cho Hwa} and Guh, {Jih Hwa} and Wang, {Shih Wei} and Sun, {Hui Lung} and Liu, {Yi Nan} and Chen, {Chien Chih} and Shen, {Chien Chang} and Chang, {Ya Ling} and Teng, {Che Ming}",

year = "2010",

month = jun,

doi = "10.1016/j.canlet.2009.11.020",

language = "English",

volume = "292",

pages = "163--170",

journal = "Cancer Letters",

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publisher = "Elsevier Ireland Ltd",

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T1 - Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo

AU - Tsai, An Chi

AU - Pan, Shiow Lin

AU - Liao, Cho Hwa

AU - Guh, Jih Hwa

AU - Wang, Shih Wei

AU - Sun, Hui Lung

AU - Liu, Yi Nan

AU - Chen, Chien Chih

AU - Shen, Chien Chang

AU - Chang, Ya Ling

AU - Teng, Che Ming

PY - 2010/6

Y1 - 2010/6

N2 - Attacking angiogenesis is considered an effective strategy for controls the expansion and metastasis of tumors and other related-diseases. The aim of this study was to assess the effects of moscatilin, a bibenzyl derivative, on VEGF and bFGF-induced angiogenesis in cultured human umbilical vein endothelial cells (HUVECs) in vitro and in vivo. Moscatilin significantly inhibited growth of lung cancer cell line A549 (NSCLC) and suppressed growth factor-induced neovascularization. In addition, VEGF- and bFGF-induced cell proliferation, migration, and tube formation of HUVECs was markedly inhibited by moscatilin. Western blotting analysis of cell signaling molecules indicated that moscatilin inhibited ERK1/2, Akt, and eNOS signaling pathways in HUVECs. These results suggest that inhibition of angiogenesis by moscatilin may be a major mechanism in cancer therapy.

AB - Attacking angiogenesis is considered an effective strategy for controls the expansion and metastasis of tumors and other related-diseases. The aim of this study was to assess the effects of moscatilin, a bibenzyl derivative, on VEGF and bFGF-induced angiogenesis in cultured human umbilical vein endothelial cells (HUVECs) in vitro and in vivo. Moscatilin significantly inhibited growth of lung cancer cell line A549 (NSCLC) and suppressed growth factor-induced neovascularization. In addition, VEGF- and bFGF-induced cell proliferation, migration, and tube formation of HUVECs was markedly inhibited by moscatilin. Western blotting analysis of cell signaling molecules indicated that moscatilin inhibited ERK1/2, Akt, and eNOS signaling pathways in HUVECs. These results suggest that inhibition of angiogenesis by moscatilin may be a major mechanism in cancer therapy.

KW - Angiogenesis

KW - BFGF

KW - Endothelial cells

KW - Moscatilin

KW - VEGF

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DO - 10.1016/j.canlet.2009.11.020

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SN - 0304-3835

VL - 292

SP - 163

EP - 170

JO - Cancer Letters

JF - Cancer Letters

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ER -

Moscatilin, a bibenzyl derivative from the India orchid Dendrobrium loddigesii, suppresses tumor angiogenesis and growth in vitro and in vivo

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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