TY - JOUR
T1 - Molecular structure of r(GCG)d(TATACGC)
T2 - A DNA-RNA hybrid helix joined to double helical DNA
AU - Wang, Andrew H.J.
AU - Fujii, Satoshi
AU - Van Boom, Jacques H.
AU - Van Der Marel, Gijs A.
AU - Van Boeckel, Stan A.A.
AU - Rich, Alexander
PY - 1982
Y1 - 1982
N2 - The molecule r(GCG)d(TATACGC) is self-complementary and forms two DNA-RNA hybrid segments surrounding a central region of double helical DNA its molecular structure has been solved by X-ray analysis. All three parts of the molecule adopt a conformation which is close to that seen in the 11-fold RNA double helix. The conformation of the ribonucleotides is partly determined by water molecules bridging between the ribose O2′ hydroxyl group and cytosine O2. The hybrid-DNA duplex junction contains no structural discontinuities. However, the central DNA TATA sequence has some structural irregularities.
AB - The molecule r(GCG)d(TATACGC) is self-complementary and forms two DNA-RNA hybrid segments surrounding a central region of double helical DNA its molecular structure has been solved by X-ray analysis. All three parts of the molecule adopt a conformation which is close to that seen in the 11-fold RNA double helix. The conformation of the ribonucleotides is partly determined by water molecules bridging between the ribose O2′ hydroxyl group and cytosine O2. The hybrid-DNA duplex junction contains no structural discontinuities. However, the central DNA TATA sequence has some structural irregularities.
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U2 - 10.1038/299601a0
DO - 10.1038/299601a0
M3 - Article
C2 - 6181416
AN - SCOPUS:0020317728
SN - 0028-0836
VL - 299
SP - 601
EP - 604
JO - Nature
JF - Nature
IS - 5884
ER -