Molecular structure of a left-Handed double helical DNA fragment at atomic resolution

Andrew H.J. Wang; Gary J. Quigley; Francis J. Kolpak; James L. Crawford; Jacques H. Van Boom; Gijs Van Der Marel; Alexander Rich

doi:10.1038/282680a0

Molecular structure of a left-Handed double helical DNA fragment at atomic resolution

Andrew H.J. Wang, Gary J. Quigley, Francis J. Kolpak, James L. Crawford, Jacques H. Van Boom, Gijs Van Der Marel, Alexander Rich

Research output: Contribution to journal › Article › peer-review

1686 Citations (Scopus)

Abstract

The DNA fragment d(CpGpCpGpCpG) crystallises as a left-handed double helical molecule with Watson-Crick base pairs and an antiparallel organisation of the sugar phosphate chains. The helix has two nucleotides in the asymmetric unit and contains twelve base pairs per turn. It differs significantly from right-handed B-DNA.

Original language	English
Pages (from-to)	680-686
Number of pages	7
Journal	Nature
Volume	282
Issue number	5740
DOIs	https://doi.org/10.1038/282680a0
Publication status	Published - 1979
Externally published	Yes

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title = "Molecular structure of a left-Handed double helical DNA fragment at atomic resolution",

abstract = "The DNA fragment d(CpGpCpGpCpG) crystallises as a left-handed double helical molecule with Watson-Crick base pairs and an antiparallel organisation of the sugar phosphate chains. The helix has two nucleotides in the asymmetric unit and contains twelve base pairs per turn. It differs significantly from right-handed B-DNA.",

author = "Wang, {Andrew H.J.} and Quigley, {Gary J.} and Kolpak, {Francis J.} and Crawford, {James L.} and {Van Boom}, {Jacques H.} and {Van Der Marel}, Gijs and Alexander Rich",

year = "1979",

doi = "10.1038/282680a0",

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T1 - Molecular structure of a left-Handed double helical DNA fragment at atomic resolution

AU - Wang, Andrew H.J.

AU - Quigley, Gary J.

AU - Kolpak, Francis J.

AU - Crawford, James L.

AU - Van Boom, Jacques H.

AU - Van Der Marel, Gijs

AU - Rich, Alexander

PY - 1979

Y1 - 1979

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AB - The DNA fragment d(CpGpCpGpCpG) crystallises as a left-handed double helical molecule with Watson-Crick base pairs and an antiparallel organisation of the sugar phosphate chains. The helix has two nucleotides in the asymmetric unit and contains twelve base pairs per turn. It differs significantly from right-handed B-DNA.

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Molecular structure of a left-Handed double helical DNA fragment at atomic resolution

Abstract

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