Molecular structure of a double helical DNA fragment intercalator complex between deoxy CpG and a terpyridine platinum compound

Andrew H.J. Wang; Jeremy Nathans; G. Van Der Marel; J. H. Van Boom; Alexander Rich

doi:10.1038/276471a0

Molecular structure of a double helical DNA fragment intercalator complex between deoxy CpG and a terpyridine platinum compound

Andrew H.J. Wang, Jeremy Nathans, G. Van Der Marel, J. H. Van Boom, Alexander Rich

Research output: Contribution to journal › Article › peer-review

201 Citations (Scopus)

Abstract

The crystal structure of a complex containing deoxy CpG and a terpyridine platinum compound (TPH) shows a DNA double helical fragment with TPH intercalated between two Watson-Crick GC base pairs. The DNA unwinding angle is 23° and the pucker of the deoxyribose rings differ at the 3′ and 5′ ends.

Original language	English
Pages (from-to)	471-474
Number of pages	4
Journal	Nature
Volume	276
Issue number	5687
DOIs	https://doi.org/10.1038/276471a0
Publication status	Published - 1978
Externally published	Yes

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title = "Molecular structure of a double helical DNA fragment intercalator complex between deoxy CpG and a terpyridine platinum compound",

abstract = "The crystal structure of a complex containing deoxy CpG and a terpyridine platinum compound (TPH) shows a DNA double helical fragment with TPH intercalated between two Watson-Crick GC base pairs. The DNA unwinding angle is 23° and the pucker of the deoxyribose rings differ at the 3′ and 5′ ends.",

author = "Wang, {Andrew H.J.} and Jeremy Nathans and {Van Der Marel}, G. and {Van Boom}, {J. H.} and Alexander Rich",

year = "1978",

doi = "10.1038/276471a0",

language = "English",

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journal = "Nature",

issn = "0028-0836",

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T1 - Molecular structure of a double helical DNA fragment intercalator complex between deoxy CpG and a terpyridine platinum compound

AU - Wang, Andrew H.J.

AU - Nathans, Jeremy

AU - Van Der Marel, G.

AU - Van Boom, J. H.

AU - Rich, Alexander

PY - 1978

Y1 - 1978

N2 - The crystal structure of a complex containing deoxy CpG and a terpyridine platinum compound (TPH) shows a DNA double helical fragment with TPH intercalated between two Watson-Crick GC base pairs. The DNA unwinding angle is 23° and the pucker of the deoxyribose rings differ at the 3′ and 5′ ends.

AB - The crystal structure of a complex containing deoxy CpG and a terpyridine platinum compound (TPH) shows a DNA double helical fragment with TPH intercalated between two Watson-Crick GC base pairs. The DNA unwinding angle is 23° and the pucker of the deoxyribose rings differ at the 3′ and 5′ ends.

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U2 - 10.1038/276471a0

DO - 10.1038/276471a0

M3 - Article

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EP - 474

JO - Nature

JF - Nature

IS - 5687

ER -

Molecular structure of a double helical DNA fragment intercalator complex between deoxy CpG and a terpyridine platinum compound

Abstract

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