TY - JOUR
T1 - Molecular Mechanisms of Chemotherapy Resistance in Head and Neck Cancers
AU - Kanno, Yuzuka
AU - Chen, Chang Yu
AU - Lee, Hsin Lun
AU - Chiou, Jeng Fong
AU - Chen, Yin Ju
N1 - Funding Information:
This work was financially supported by the ?TMU Research Center of Cancer Translational Medicine? from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan and also partially supported by the Ministry of Science Taiwan (MOST 109-2635-B-038-001). We thank the support from Translational Laboratory, Department of Medical Research, Taipei Medical University Hospital for space support.
Publisher Copyright:
© Copyright © 2021 Kanno, Chen, Lee, Chiou and Chen.
PY - 2021/5/7
Y1 - 2021/5/7
N2 - Chemotherapy resistance is a huge barrier for head and neck cancer (HNC) patients and therefore requires close attention to understand its underlay mechanisms for effective strategies. In this review, we first summarize the molecular mechanisms of chemotherapy resistance that occur during the treatment with cisplatin, 5-fluorouracil, and docetaxel/paclitaxel, including DNA/RNA damage repair, drug efflux, apoptosis inhibition, and epidermal growth factor receptor/focal adhesion kinase/nuclear factor-κB activation. Next, we describe the potential approaches to combining conventional therapies with previous cancer treatments such as immunotherapy, which may improve the treatment outcomes and prolong the survival of HNC patients. Overall, by parsing the reported molecular mechanisms of chemotherapy resistance within HNC patient’s tumors, we can improve the prediction of chemotherapeutic responsiveness, and reveal new therapeutic targets for the future.
AB - Chemotherapy resistance is a huge barrier for head and neck cancer (HNC) patients and therefore requires close attention to understand its underlay mechanisms for effective strategies. In this review, we first summarize the molecular mechanisms of chemotherapy resistance that occur during the treatment with cisplatin, 5-fluorouracil, and docetaxel/paclitaxel, including DNA/RNA damage repair, drug efflux, apoptosis inhibition, and epidermal growth factor receptor/focal adhesion kinase/nuclear factor-κB activation. Next, we describe the potential approaches to combining conventional therapies with previous cancer treatments such as immunotherapy, which may improve the treatment outcomes and prolong the survival of HNC patients. Overall, by parsing the reported molecular mechanisms of chemotherapy resistance within HNC patient’s tumors, we can improve the prediction of chemotherapeutic responsiveness, and reveal new therapeutic targets for the future.
KW - chemotherapy
KW - chemotherapy resistance
KW - combination therapy
KW - head and neck cancer
KW - immunotherapy
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U2 - 10.3389/fonc.2021.640392
DO - 10.3389/fonc.2021.640392
M3 - Review article
AN - SCOPUS:85106169945
SN - 2234-943X
VL - 11
JO - Frontiers in Oncology
JF - Frontiers in Oncology
M1 - 640392
ER -
