Molecular epidemiology of multidrug-resistant Mycobacterium tuberculosis in Eastern Taiwan

A. H. Hsu; C. B. Lin; Y. S. Lee; C. Y. Chiang; L. K. Chen; Y. S. Tsai; Jen Jyh Lee

Molecular epidemiology of multidrug-resistant Mycobacterium tuberculosis in Eastern Taiwan

A. H. Hsu, C. B. Lin, Y. S. Lee, C. Y. Chiang, L. K. Chen, Y. S. Tsai, Jen Jyh Lee

Research output: Contribution to journal › Article › peer-review

Abstract

Taiwan initiated a multidrug-resistant tuberculosis (MDR-TB) programme in May 2007. Seventy-seven MDR-TB patients were enrolled from May 2007 to February 2009 in Eastern Taiwan. Isolates of 73 (94%) patients were available for genotyping using spoligotyping and MIRU-VNTR (mycobacterial interspersed repetitive unit-v ariable number of tandem repeats). Spoligotyping results indicated the Beijing strain as the predominant genotype (n = 48, 66%). Of the 73 isolates, 28 (38.4%) had a unique pattern and 45 (61.6%) were clustered pattern strains. Epidemiological links could be established in 21 (46.7%) of the 45 patients with a clustered pattern strain. The proportion of MDR-TB patients with a clustered pattern strain in Eastern Taiwan was high.

Original language	English
Pages (from-to)	924-926
Number of pages	3
Journal	International Journal of Tuberculosis and Lung Disease
Volume	14
Issue number	7
Publication status	Published - Jul 2010
Externally published	Yes

Keywords

MIRU-VNTR
Multidrug-resistant tuberculosis
Spoligo-typing
Transmission

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{70854d95d8c8433ebcc1d727e1ae4b4f,

title = "Molecular epidemiology of multidrug-resistant Mycobacterium tuberculosis in Eastern Taiwan",

abstract = "Taiwan initiated a multidrug-resistant tuberculosis (MDR-TB) programme in May 2007. Seventy-seven MDR-TB patients were enrolled from May 2007 to February 2009 in Eastern Taiwan. Isolates of 73 (94%) patients were available for genotyping using spoligotyping and MIRU-VNTR (mycobacterial interspersed repetitive unit-v ariable number of tandem repeats). Spoligotyping results indicated the Beijing strain as the predominant genotype (n = 48, 66%). Of the 73 isolates, 28 (38.4%) had a unique pattern and 45 (61.6%) were clustered pattern strains. Epidemiological links could be established in 21 (46.7%) of the 45 patients with a clustered pattern strain. The proportion of MDR-TB patients with a clustered pattern strain in Eastern Taiwan was high.",

keywords = "MIRU-VNTR, Multidrug-resistant tuberculosis, Spoligo-typing, Transmission",

author = "Hsu, {A. H.} and Lin, {C. B.} and Lee, {Y. S.} and Chiang, {C. Y.} and Chen, {L. K.} and Tsai, {Y. S.} and Lee, {Jen Jyh}",

year = "2010",

month = jul,

language = "English",

volume = "14",

pages = "924--926",

journal = "International Journal of Tuberculosis and Lung Disease",

issn = "1027-3719",

publisher = "International Union against Tubercul. and Lung Dis.",

number = "7",

}

TY - JOUR

T1 - Molecular epidemiology of multidrug-resistant Mycobacterium tuberculosis in Eastern Taiwan

AU - Hsu, A. H.

AU - Lin, C. B.

AU - Lee, Y. S.

AU - Chiang, C. Y.

AU - Chen, L. K.

AU - Tsai, Y. S.

AU - Lee, Jen Jyh

PY - 2010/7

Y1 - 2010/7

N2 - Taiwan initiated a multidrug-resistant tuberculosis (MDR-TB) programme in May 2007. Seventy-seven MDR-TB patients were enrolled from May 2007 to February 2009 in Eastern Taiwan. Isolates of 73 (94%) patients were available for genotyping using spoligotyping and MIRU-VNTR (mycobacterial interspersed repetitive unit-v ariable number of tandem repeats). Spoligotyping results indicated the Beijing strain as the predominant genotype (n = 48, 66%). Of the 73 isolates, 28 (38.4%) had a unique pattern and 45 (61.6%) were clustered pattern strains. Epidemiological links could be established in 21 (46.7%) of the 45 patients with a clustered pattern strain. The proportion of MDR-TB patients with a clustered pattern strain in Eastern Taiwan was high.

AB - Taiwan initiated a multidrug-resistant tuberculosis (MDR-TB) programme in May 2007. Seventy-seven MDR-TB patients were enrolled from May 2007 to February 2009 in Eastern Taiwan. Isolates of 73 (94%) patients were available for genotyping using spoligotyping and MIRU-VNTR (mycobacterial interspersed repetitive unit-v ariable number of tandem repeats). Spoligotyping results indicated the Beijing strain as the predominant genotype (n = 48, 66%). Of the 73 isolates, 28 (38.4%) had a unique pattern and 45 (61.6%) were clustered pattern strains. Epidemiological links could be established in 21 (46.7%) of the 45 patients with a clustered pattern strain. The proportion of MDR-TB patients with a clustered pattern strain in Eastern Taiwan was high.

KW - MIRU-VNTR

KW - Multidrug-resistant tuberculosis

KW - Spoligo-typing

KW - Transmission

UR - http://www.scopus.com/inward/record.url?scp=77953638456&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953638456&partnerID=8YFLogxK

M3 - Article

C2 - 20550780

AN - SCOPUS:77953638456

SN - 1027-3719

VL - 14

SP - 924

EP - 926

JO - International Journal of Tuberculosis and Lung Disease

JF - International Journal of Tuberculosis and Lung Disease

IS - 7

ER -

Molecular epidemiology of multidrug-resistant Mycobacterium tuberculosis in Eastern Taiwan

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Other files and links

Fingerprint

Cite this