Abstract
To understand the trends of distribution and risk factors associated with different HIV-I subtypes in different populations in Taiwan, blood samples and questionnaires were collected from 267 male and 21 female HIV-1- infected people in a multicenter survey from 1993 to 1996. This group represented about one quarter of the total registered HIV-1 cases in Taiwan. The HIV-1 subtypes were determined using V3-based peptide-enzyme immunoassays complemented by heteroduplex mobility assay and phylogenetic tree analysis. The results showed that in Taiwan, men were primarily infected with HIV-1B (68.2%) and HIV-1E (27.3%), whereas women were mainly infected with non-B subtypes (4.8% A, 4.8% C, 71.4% E, and 9.5% G). In addition, 71.4% of men with HIV-1B were homosexual or bisexual, whereas 56.2% of men with HIV-1E were heterosexual (p < .001). Although HIV-1E subtype came to Taiwan later than HIV-1B, it has become a major subtype in the heterosexual population.
Original language | English |
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Pages (from-to) | 393-402 |
Number of pages | 10 |
Journal | Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology |
Volume | 19 |
Issue number | 4 |
DOIs | |
Publication status | Published - Dec 1 1998 |
Externally published | Yes |
Keywords
- Heteroduplex mobility assay
- HIV-1 genetic sequences
- HIV-1 subtypes
- Molecular epidemiology
- Taiwan
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Virology