Molecular epidemiology and clinical features of rhinovirus infections among hospitalized patients in a medical center in Taiwan

Huei Min Hung, Shu Li Yang, Chih Jung Chen, Cheng Hsun Chiu, Chen Yen Kuo, Kuan Ying A. Huang, Tzou Yien Lin, Yu Chia Hsieh, Yu Nong Gong, Kuo Chien Tsao, Yhu Chering Huang

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)


Background: Human rhinovirus (HRV) can cause severe illnesses in hospitalized patients. However, there are no studies regarding the prevalence of HRV infection, particularly the recently identified HRV-C, in hospitalized patients reported from Taiwan. Methods: Respiratory specimens collected from 487 hospitalized patients in designated wards between 2013 and 2014 in a medical center in northern Taiwan were retrospectively detected for HRV. Positive specimens were further determined for genotyping. Medical charts of the HRV-positive patients were reviewed retrospectively. Results: Totally, 76 patients (15.6%) were HRV positive, of which 60 were pediatric patients. HRV-A was identified in 41 (54%) patients, HRV-B in 6 patients (7.9%) and HRV-C in 29 patients (38%). A total of 47 different genotypes were identified. HRV infections were predominant during fall and winter seasons. 21.1% were affected by HRV alone and 78.9% were found to be co-infected with other microorganisms. The detection rate of HRV in children (18.6%) was significantly higher than in adults (9.6%). Compared with pediatric patients, adult patients were significantly associated with underlying disease, Pneumocystis jirovesii pneumonia co-infection, a diagnosis of pneumonia, fatal outcome, hospital acquisition of HRV, antibiotics administration and requiring intensive care, while pediatric patients were significantly associated with viral co-infection. Conclusions: HRV was a common cause of respiratory tract infection in Taiwan, particularly in pediatric patients. Eighty percent of HRV-infected inpatients had other microorganisms co-infection. Adult patients were more likely to be associated with a severe respiratory disease entity.

Original languageEnglish
Pages (from-to)233-241
Number of pages9
JournalJournal of Microbiology, Immunology and Infection
Issue number2
Publication statusPublished - Apr 2019


  • Hospitalized patients
  • Respiratory tract infection
  • Rhinovirus
  • Taiwan

ASJC Scopus subject areas

  • Immunology and Allergy
  • General Immunology and Microbiology
  • Microbiology (medical)
  • Infectious Diseases


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