Molecular and Genetics-Based Systems for Tracing the Evolution and Exploring the Mechanisms of Human Norovirus Infections

Sheng Chieh Lin, Geng Hao Bai, Pei Chun Lin, Chung Yung Chen, Yi Hsiang Hsu, Yuan Chang Lee, Shih Yen Chen

Research output: Contribution to journalReview articlepeer-review

Abstract

Human noroviruses (HuNoV) are major causes of acute gastroenteritis around the world. The high mutation rate and recombination potential of noroviruses are significant challenges in studying the genetic diversity and evolution pattern of novel strains. In this review, we describe recent advances in the development of technologies for not only the detection but also the analysis of complete genome sequences of noroviruses and the future prospects of detection methods for tracing the evolution and genetic diversity of human noroviruses. The mechanisms of HuNoV infection and the development of antiviral drugs have been hampered by failure to develop the infectious virus in a cell model. However, recent studies have demonstrated the potential of reverse genetics for the recovery and generation of infectious viral particles, suggesting the utility of this genetics-based system as an alternative for studying the mechanisms of viral infection, such as cell entry and replication.

Original languageEnglish
Article number9093
JournalInternational journal of molecular sciences
Volume24
Issue number10
DOIs
Publication statusPublished - May 2023

Keywords

  • evolution
  • genetics-based systems
  • human noroviruses
  • recombination
  • reverse genetics

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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