Modulation of AKT Pathway-Targeting miRNAs for Cancer Cell Treatment with Natural Products

Jun Ping Shiau; Ya Ting Chuang; Ching Yu Yen; Fang Rong Chang; Kun Han Yang; Ming Feng Hou; Jen Yang Tang; Hsueh Wei Chang

doi:10.3390/ijms24043688

Modulation of AKT Pathway-Targeting miRNAs for Cancer Cell Treatment with Natural Products

Jun Ping Shiau, Ya Ting Chuang, Ching Yu Yen, Fang Rong Chang, Kun Han Yang, Ming Feng Hou, Jen Yang Tang, Hsueh Wei Chang

School of Dentistry

Research output: Contribution to journal › Review article › peer-review

13 Citations (Scopus)

Abstract

Many miRNAs are known to target the AKT serine-threonine kinase (AKT) pathway, which is critical for the regulation of several cell functions in cancer cell development. Many natural products exhibiting anticancer effects have been reported, but their connections to the AKT pathway (AKT and its effectors) and miRNAs have rarely been investigated. This review aimed to demarcate the relationship between miRNAs and the AKT pathway during the regulation of cancer cell functions by natural products. Identifying the connections between miRNAs and the AKT pathway and between miRNAs and natural products made it possible to establish an miRNA/AKT/natural product axis to facilitate a better understanding of their anticancer mechanisms. Moreover, the miRNA database (miRDB) was used to retrieve more AKT pathway-related target candidates for miRNAs. By evaluating the reported facts, the cell functions of these database-generated candidates were connected to natural products. Therefore, this review provides a comprehensive overview of the natural product/miRNA/AKT pathway in the modulation of cancer cell development.

Original language	English
Article number	3688
Journal	International journal of molecular sciences
Volume	24
Issue number	4
DOIs	https://doi.org/10.3390/ijms24043688
Publication status	Published - Feb 2023

Keywords

AKT
bioactive substance
cell function
miRNA
natural products

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms24043688

Cite this

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title = "Modulation of AKT Pathway-Targeting miRNAs for Cancer Cell Treatment with Natural Products",

abstract = "Many miRNAs are known to target the AKT serine-threonine kinase (AKT) pathway, which is critical for the regulation of several cell functions in cancer cell development. Many natural products exhibiting anticancer effects have been reported, but their connections to the AKT pathway (AKT and its effectors) and miRNAs have rarely been investigated. This review aimed to demarcate the relationship between miRNAs and the AKT pathway during the regulation of cancer cell functions by natural products. Identifying the connections between miRNAs and the AKT pathway and between miRNAs and natural products made it possible to establish an miRNA/AKT/natural product axis to facilitate a better understanding of their anticancer mechanisms. Moreover, the miRNA database (miRDB) was used to retrieve more AKT pathway-related target candidates for miRNAs. By evaluating the reported facts, the cell functions of these database-generated candidates were connected to natural products. Therefore, this review provides a comprehensive overview of the natural product/miRNA/AKT pathway in the modulation of cancer cell development.",

keywords = "AKT, bioactive substance, cell function, miRNA, natural products",

author = "Shiau, {Jun Ping} and Chuang, {Ya Ting} and Yen, {Ching Yu} and Chang, {Fang Rong} and Yang, {Kun Han} and Hou, {Ming Feng} and Tang, {Jen Yang} and Chang, {Hsueh Wei}",

note = "Funding Information: This study was partly supported by funds from the Ministry of Science and Technology (MOST 111-2320-B-037-015-MY3 and MOST 110-2314-B-037-074-MY3), the Kaohsiung Medical University (KMU-DK(A)111008), and the Kaohsiung Medical University Research Center (KMU-TC108A04). Publisher Copyright: {\textcopyright} 2023 by the authors.",

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doi = "10.3390/ijms24043688",

language = "English",

volume = "24",

journal = "International journal of molecular sciences",

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AU - Shiau, Jun Ping

AU - Chuang, Ya Ting

AU - Yen, Ching Yu

AU - Chang, Fang Rong

AU - Yang, Kun Han

AU - Hou, Ming Feng

AU - Tang, Jen Yang

AU - Chang, Hsueh Wei

N1 - Funding Information: This study was partly supported by funds from the Ministry of Science and Technology (MOST 111-2320-B-037-015-MY3 and MOST 110-2314-B-037-074-MY3), the Kaohsiung Medical University (KMU-DK(A)111008), and the Kaohsiung Medical University Research Center (KMU-TC108A04). Publisher Copyright: © 2023 by the authors.

PY - 2023/2

Y1 - 2023/2

N2 - Many miRNAs are known to target the AKT serine-threonine kinase (AKT) pathway, which is critical for the regulation of several cell functions in cancer cell development. Many natural products exhibiting anticancer effects have been reported, but their connections to the AKT pathway (AKT and its effectors) and miRNAs have rarely been investigated. This review aimed to demarcate the relationship between miRNAs and the AKT pathway during the regulation of cancer cell functions by natural products. Identifying the connections between miRNAs and the AKT pathway and between miRNAs and natural products made it possible to establish an miRNA/AKT/natural product axis to facilitate a better understanding of their anticancer mechanisms. Moreover, the miRNA database (miRDB) was used to retrieve more AKT pathway-related target candidates for miRNAs. By evaluating the reported facts, the cell functions of these database-generated candidates were connected to natural products. Therefore, this review provides a comprehensive overview of the natural product/miRNA/AKT pathway in the modulation of cancer cell development.

AB - Many miRNAs are known to target the AKT serine-threonine kinase (AKT) pathway, which is critical for the regulation of several cell functions in cancer cell development. Many natural products exhibiting anticancer effects have been reported, but their connections to the AKT pathway (AKT and its effectors) and miRNAs have rarely been investigated. This review aimed to demarcate the relationship between miRNAs and the AKT pathway during the regulation of cancer cell functions by natural products. Identifying the connections between miRNAs and the AKT pathway and between miRNAs and natural products made it possible to establish an miRNA/AKT/natural product axis to facilitate a better understanding of their anticancer mechanisms. Moreover, the miRNA database (miRDB) was used to retrieve more AKT pathway-related target candidates for miRNAs. By evaluating the reported facts, the cell functions of these database-generated candidates were connected to natural products. Therefore, this review provides a comprehensive overview of the natural product/miRNA/AKT pathway in the modulation of cancer cell development.

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Modulation of AKT Pathway-Targeting miRNAs for Cancer Cell Treatment with Natural Products

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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